Cellular environments and apoptosis: Tissue microenvironments control activated T-cell death

被引：196
作者：
Akbar, AN
Salmon, M
机构：
[1] UNIV BIRMINGHAM, SCH MED, DEPT RHEUMATOL, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND
[2] ROYAL FREE HOSP, SCH MED, DEPT CLIN IMMUNOL, LONDON NW3 2QG, ENGLAND
来源：
IMMUNOLOGY TODAY | 1997年 / 18卷 / 02期
关键词：
D O I：
10.1016/S0167-5699(97)01003-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Activated T cells must be removed by apoptosis at the end of an immune response in order to maintain cellular homeostasis. Although recent attention has focused on the role of CD95 (Fas/APO-1) in the elimination of activated T cells, apoptosis can also be induced by cytokine deprivation. Here, Arne Akbar and Mike Salmon describe how both death pathways interact in activated T cells and are profoundly influenced by different tissue microenvironments.
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页码：72 / 76
页数：5
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