Lipid-protein interplay and lateral organization in biomembranes

被引:49
|
作者
Nyholm, Thomas K. M. [1 ]
机构
[1] Abo Akad Univ, Biochem, Biosci, Fac Sci & Engn, FIN-20520 Turku, Finland
关键词
Membrane raft; Protein-lipid interactions; Liquid ordered phase; Cholesterol; INFLUENZA-VIRUS HEMAGGLUTININ; ALPHA-HELICAL PEPTIDES; PLASMA-MEMBRANE; HYDROPHOBIC MISMATCH; TRANSMEMBRANE PEPTIDES; RAFT ASSOCIATION; MODEL MEMBRANES; LIQUID DOMAINS; BILAYERS; CHOLESTEROL;
D O I
10.1016/j.chemphyslip.2015.05.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The distribution of lipids and membrane proteins within and between cellular membranes is carefully regulated. This sorting of lipids and proteins results in compositional differences between membrane compartments, bilayer leaflets, and lateral domains in the bilayer plane. The lateral organization of lipids and proteins has proven challenging to investigate, and the driving mechanisms remains unclear. Lipid self-organization has an essential role in the formation of lateral membrane structure, but the role of transmembrane proteins is not well known. This review focuses on how lateral lipid structure can affect the lateral distribution of proteins and how proteins could influence the organization of lipids in biomembranes. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:48 / 55
页数:8
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