The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies

被引：73

作者：

Farrugia, Brooke L. ^{[1
]}

Lord, Megan S. ^{[1
]}

Melrose, James ^{[1
,2
,3
]}

Whitelock, John M. ^{[1
]}

机构：

[1] Univ New South Wales Sydney, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia

[2] Northern Sydney Local Hlth Dist, Kolling Inst, Raymond Purves Bone & Joint Res Lab, St Leonards, NSW, Australia

[3] Univ Sydney, Royal North Shore Hosp, Sydney Med Sch Northern, St Leonards, NSW, Australia

来源：

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 2018年 / 66卷 / 04期

基金：

澳大利亚研究理事会;

关键词：

extracellular matrix; glycosaminoglycans; heparan sulfate; heparin; inflammation; innate immunity; MONOCYTE CHEMOATTRACTANT PROTEIN-1; CHEMOKINE-GLYCOSAMINOGLYCAN INTERACTIONS; SUBENDOTHELIAL EXTRACELLULAR-MATRIX; FIBROBLAST-GROWTH-FACTOR; ACTIVITY IN-VITRO; L-SELECTIN; ENDOTHELIAL-CELLS; P-SELECTIN; DIABETIC-NEPHROPATHY; BASEMENT-MEMBRANE;

D O I：

10.1369/0022155417740881

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Key events that occur during inflammation include the recruitment, adhesion, and transmigration of leukocytes from the circulation to the site of inflammation. These events are modulated by chemokines, integrins, and selectins and the interaction of these molecules with glycosaminoglycans, predominantly heparan sulfate (HS). The development of HS/heparin mimetics that interfere or inhibit the interactions that occur between glycosaminoglycans and modulators of inflammation holds great potential for use as anti-inflammatory therapeutics. This review will detail the role of HS in the events that occur during inflammation, their interaction and modulation of inflammatory mediators, and the current advances in the development of HS/heparin mimetics as anti-inflammatory biotherapeutics.

引用

页码：321 / 336

页数：16

共 130 条

[1] A non-glycosaminoglycan-binding variant of CC chemokine ligand 7 (monocyte chemoattractant protein-3) antagonizes chemokine-mediated inflammation [J].

Ali, S ;

Robertson, H ;

Wain, JH ;

Isaacs, JD ;

Malik, G ;

Kirby, JA .

JOURNAL OF IMMUNOLOGY, 2005, 175 (02) :1257-1266

[2] Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice [J].

Axelsson, Jakob ;

Xu, Ding ;

Kang, Bit Na ;

Nussbacher, Julia K. ;

Handel, Tracy M. ;

Ley, Klaus ;

Sriramarao, P. ;

Esko, Jeffrey D. .

BLOOD, 2012, 120 (08) :1742-1751

[3] Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes [J].

Bao, Xingfeng ;

Moseman, E. Ashley ;

Saito, Hideo ;

Petryanik, Bronislawa ;

Thiriot, Aude ;

Hatakeyama, Shingo ;

Ito, Yuki ;

Kawashima, Hiroto ;

Yamaguchi, Yu ;

Lowe, John B. ;

von Andrian, Ulrich H. ;

Fukuda, Minoru .

IMMUNITY, 2010, 33 (05) :817-829

[4] CCL2 nitration is a negative regulator of chemokine-mediated inflammation [J].

Barker, Catriona E. ;

Thompson, Sarah ;

O'Boyle, Graeme ;

Lortat-Jacob, Hugues ;

Sheerin, Neil S. ;

Ali, Simi ;

Kirby, John A. .

SCIENTIFIC REPORTS, 2017, 7

[5] COMPARATIVE-ANALYSIS OF THE ABILITY OF LEUKOCYTES, ENDOTHELIAL-CELLS AND PLATELETS TO DEGRADE THE SUBENDOTHELIAL BASEMENT-MEMBRANE - EVIDENCE FOR CYTOKINE DEPENDENCE AND DETECTION OF A NOVEL SULFATASE [J].

BARTLETT, MR ;

UNDERWOOD, PA ;

PARISH, CR .

IMMUNOLOGY AND CELL BIOLOGY, 1995, 73 (02) :113-124

[6]

BASHKIN P, 1990, BLOOD, V75, P2204

[7] Translocation of active heparanase to cell surface regulates degradation of extracellular matrix heparan sulfate upon transmigration of mature monocyte-derived dendritic cells [J].

Benhamron, Sandrine ;

Nechushtan, Hovav ;

Verbovetski, Inna ;

Krispin, Alon ;

Abboud-Jarrous, Ghada ;

Zcharia, Eyal ;

Edovitsky, Evgeny ;

Nahari, Efrat ;

Peretz, Tamar ;

Vlodavsky, Israel ;

Mevorach, Dror .

JOURNAL OF IMMUNOLOGY, 2006, 176 (11) :6417-6424

[8] Heparan sulphate proteoglycans fine-tune mammalian physiology [J].

Bishop, Joseph R. ;

Schuksz, Manuela ;

Esko, Jeffrey D. .

NATURE, 2007, 446 (7139) :1030-1037

[9] Macrophage Activation by Heparanase Is Mediated by TLR-2 and TLR-4 and Associates With Plaque Progression [J].

Blich, Miry ;

Golan, Amnon ;

Arvatz, Gil ;

Sebbag, Anat ;

Shafat, Itay ;

Sabo, Edmond ;

Cohen-Kaplan, Victoria ;

Petcherski, Sirouch ;

Avniel-Polak, Shani ;

Eitan, Amnon ;

Hammerman, Haim ;

Aronson, Doron ;

Axelman, Elena ;

Ilan, Neta ;

Nussbaum, Gabriel ;

Vlodavsky, Israel .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2013, 33 (02) :E56-+

[10] Structural modification of fibroblast growth factor-binding heparan sulfate at a determinative stage of neural development [J].

Brickman, YG ;

Ford, MD ;

Gallagher, JT ;

Nurcombe, V ;

Bartlett, PF ;

Turnbull, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (08) :4350-4359

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