Intersection of the stringent response and the CodY regulon in low GC Gram-positive bacteria

被引:81
|
作者
Geiger, Tobias [1 ]
Wolz, Christiane [1 ]
机构
[1] Univ Tubingen, Interfac Inst Microbiol & Infect Med, D-72076 Tubingen, Germany
关键词
Stringent response; CodY regulon; Bacillus subtilis; Listeria monocytogenes; Staphylococcus aureus; BACILLUS-SUBTILIS CODY; CHAIN AMINO-ACIDS; RNA TRANSCRIPTION REGULATION; (P)PPGPP SYNTHETASE GENES; DIPEPTIDE PERMEASE OPERON; STAPHYLOCOCCUS-AUREUS; REGULATOR CODY; LISTERIA-MONOCYTOGENES; STREPTOCOCCUS-PYOGENES; NUTRITIONAL REPRESSION;
D O I
10.1016/j.ijmm.2013.11.013
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Bacteria adapt efficiently to a wide range of nutritional environments. Therefore, they possess overlapping regulatory systems that detect intracellular pools of key metabolites. In low GC Gram-positive bacteria, two global regulators, the stringent response and the CodY repressor, respond to an intracellular decrease in amino acid content. Amino acid limitation leads to rapid synthesis of the alarmones pppGpp and ppGpp through the stringent response and inactivates the CodY repressor. Two cofactors, branched chain amino acids (SCAA) and GTP, are ligands for CodY and facilitate binding to the target DNA. Because (p)ppGpp synthesis and accumulation evidentially reduce the intracellular GTP pool, CodY is released from the DNA, and transcription of target genes is altered. Here, we focus on this intimate link between the stringent response and CodY regulation in different Gram-positive species. (C) 2013 Elsevier GmbH. All rights reserved.
引用
收藏
页码:150 / 155
页数:6
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