A Novel Rutin Electrochemical Sensor Using Reduced Graphene Oxide/Magnetite/Silver Nanoparticle-Molecularly Imprinted Polymer Composite Modified Electrode

A novel rutin (RT) electrochemical sensor was fabricated by using reduced graphene oxide (rGO)/magnetite (Fe3O4)/silver nanoparticle (Ag)-molecularly imprinted polymer (MIP) composite to modify screen-printed electrode (SPE). The ternary composite of rGO/Fe3O4/Ag was prepared by the one-step solvothermal method. Subsequently, RT molecules were absorbed on the surface of rGO/Fe3O4/Ag due to the electrostatic force. Finally, the MIP was achieved by a polymerization reaction. The prepared composite was investigated by FTIR, XRD and VSM. The morphologies and electrochemical properties of different electrodes were characterized with FE-SEM, EIS, CV and DPV. Under the optimal conditions, the SPE I rGO/Fe3O4/Ag-MIP electrode exhibited highly sensitive and selective in determining of RT. The linear detection ranges (LDRs) were 1.0x10(-2) to 10.0 mu M (R=0.9978) and 10.0 to 3.0x10(3) mu M (R=0.9965). The limit of detection (LOD) was as low as 4.2x10(-3) mu M (S/N=3). The proposed electrode was renewable, stable and reliable. It was used for determining RT in pharmaceutical samples with satisfactory results, confirming its promising application in routine RT analysis.