Preparation of multilayer films consisting of glucose oxidase and poly(amidoamine) dendrimer and their stability

被引：6
作者：
Suwa, K. [1 ]
Sato, Katsuhiko [1 ]
Anzai, J. [1 ]
机构：
[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
来源：
COLLOID AND POLYMER SCIENCE | 2015年 / 293卷 / 09期
关键词：
Phenylboronic acid; Dendrimer; Multilayer film; Glucose oxidase; BY-LAYER FILMS; CONTROLLED-RELEASE; THIN-FILMS; PHENYLBORONIC ACID; INSULIN; ASSEMBLIES; MICROCAPSULES;
D O I：
10.1007/s00396-015-3722-5
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Multilayer films comprising of glucose oxidase (GOx) and phenylboronic acid-modified poly(amidoamine) dendrimer (PBA-PAMAM) were prepared and their pH- and glucose-induced decomposition was studied. Multilayered GOx/PBA-PAMAM films were prepared through boronate ester linkages between PBA-PAMAM and carbohydrate chains of GOx. In contrast, preparation of multilayer film was unsuccessful when unmodified PAMAM was used in lieu of PBA-PAMAM, confirming an essential role of PBA residues in constructing multilayer films. The ten-layered (GOx/PBA-PAMAM)(10) film was stable in aqueous solutions of pH 8.5, whereas the multilayer film decomposed in neutral and acidic media as a result of cleavage of the boronate ester bond. The pH threshold for the film decomposition was pH 7.0-8.0. In addition, the (GOx/PBA-PAMAM)(10) film decomposed in glucose solutions owing to the oxidative scission of carbon-boron bond of PBA-PAMAM by enzymatically produced hydrogen peroxide. Thus, the potential use of the (GOx/PBA-PAMAM)(10) film for the development of pH- and glucose-sensitive devices is suggested.
引用
收藏
页码：2713 / 2718
页数：6
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