Quorum sensing systems influence Burkholderia cenocepacia virulence

被引：0
作者：
Subramoni, Sujatha [1 ]
Sokol, Pamela A. [1 ]
机构：
[1] Univ Calgary, Fac Med, Dept Microbiol Immunol & Infect Dis, Calgary, AB T2N 4N1, Canada
来源：
FUTURE MICROBIOLOGY | 2012年 / 7卷 / 12期
基金：
加拿大健康研究院;
关键词：
BDSF; biofilms; Burkholderia cenocepacia; CciR; CepR; cystic fibrosis; infection models; N-acyl homoserine lactone; quorum sensing; virulence; N-ACYLHOMOSERINE LACTONES; CONTROLS BIOFILM FORMATION; VI SECRETION SYSTEM; CEPACIA COMPLEX; GENE-EXPRESSION; REGULATED GENES; TRANSCRIPTIONAL REGULATOR; ORNIBACTIN BIOSYNTHESIS; COLONY MORPHOLOGY; IDENTIFICATION;
D O I：
10.2217/FMB.12.118
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Burkholderia cepacia complex strains communicate using N-acyl homoserine lactones and BDSF-dependent quorum sensing (QS) systems. Burkholderia cenocepacia QS systems include CepIR, CciIR, CepR2 and BDSF. Analysis of CepR, CciIR, CepR2 and RpfF (BDSF synthase) QS regulons revealed that these QS systems both independently regulate and coregulate many target genes, often in an opposing manner. The role of QS and several QS-regulated genes in virulence has been determined using vertebrate, invertebrate and plant infection models. Virulence phenotypes are strain and model dependent, suggesting that different QS-regulated genes are important depending on the strain and type of infection. QS inhibitors in combination with antibiotics can reduce biofilm formation and virulence in infection models.
引用
收藏
页码：1373 / 1387
页数：15
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