Antenatal and Postnatal Management of Congenital Cystic Adenomatoid Malformation

被引：70

作者：

Kotecha, S. ^{[1
]}

Barbato, A. ^{[2
]}

Bush, A. ^{[3
,4
]}

Claus, F. ^{[5
]}

Davenport, M. ^{[6
]}

Delacourt, C. ^{[7
]}

Deprest, J. ^{[8
]}

Eber, E. ^{[9
]}

Frenckner, B. ^{[10
]}

Greenough, A. ^{[11
]}

Nicholson, A. G. ^{[4
,12
]}

Anton-Pacheco, J. L. ^{[13
]}

Midulla, F. ^{[14
]}

机构：

[1] Cardiff Univ, Dept Child Hlth, Sch Med, Cardiff CF14 4XN, S Glam, Wales

[2] Univ Padua, Dept Pediat, Padua, Italy

[3] Univ London Imperial Coll Sci Technol & Med, Dept Paediat, Royal Brompton & Harefield NHS Fdn Trust, London, England

[4] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Div, London, England

[5] Univ Hosp Leuven, Dept Radiol, Louvain, Belgium

[6] Kings Coll Hosp London, Dept Paediat Surg, London, England

[7] Univ Paris 05, Serv Pneumol Pediat, Hop Necker, Paris, France

[8] Univ Hosp Leuven, Dept Obstet & Gynaecol, Louvain, Belgium

[9] Med Univ Graz, Univ Childrens Hosp, Dept Paediat, Graz, Austria

[10] Karolinska Inst, Dept Paediat Surg, Stockholm, Sweden

[11] Kings Coll London, Div Asthma Allergy & Lung Biol, London WC2R 2LS, England

[12] Univ London Imperial Coll Sci Technol & Med, Royal Brompton & Harefield NHS Fdn Trust, Dept Histopathol, London, England

[13] Univ Complutense Madrid, Div Pediat Surg, Hosp U Octubre 12, Madrid, Spain

[14] Univ Roma La Sapienza, Paeditr Dept, Rome, Italy

来源：

PAEDIATRIC RESPIRATORY REVIEWS | 2012年 / 13卷 / 03期

关键词：

Congenital thoracic malformation; Congenital lung malformations; Pulmonary sequestration; Pleuropulmonary blastoma; Bronchial atresia; PRIMARY PULMONARY RHABDOMYOSARCOMA; BRONCHIOLOALVEOLAR CARCINOMA; LUNG LESIONS; PLEUROPULMONARY BLASTOMA; PRENATAL-DIAGNOSIS; FOLLOW-UP; SEQUESTRATION; RESECTION; LOBECTOMY; GROWTH;

D O I：

10.1016/j.prrv.2012.01.002

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Congenital thoracic malformations (CTMs) are a heterogeneous group of rare disorders that may involve the airways or lung parenchyma. The authors have focused on the condition that causes the most controversy, namely, congenital cystic adenomatoid malformation (CCAM). The reported incidence is 3.5 and 0.94 per 10,000 live births for CTMs and CCAMs respectively. Ultrasound is the antenatal imaging modality of choice for screening for CCAMs whilst magnetic resonance imaging is complimentary for morphological and volumetric evaluation of the foetal lung. Most CCAMs are detected antenatally with only a small proportion presenting postnatally. Only a few CCAMs cause foetal problems, with foetal hydrops being the best predictor of death. Although many CCAMs regress during pregnancy, most remain detectable postnatally by CT scans. Surgical excision of symptomatic lesions is relatively straightforward, but management of asymptomatic lesions is controversial. Some surgeons adopt a "wait and see" approach operating only on those patients who develop symptoms, but others operate on asymptomatic patients usually within the first year of life. Due to the potential of malignant transformation, children should have long term follow up. There is an urgent need to delineate the natural history of antenatally detected CCAMs to guide future management. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：162 / 171

页数：10

共 122 条

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