Role for terminal complement activation in amyotrophic lateral sclerosis disease progression

被引:44
作者
Woodruff, Trent M. [1 ]
Lee, John D. [1 ]
Noakes, Peter G. [1 ,2 ]
机构
[1] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
关键词
MODEL; C5A;
D O I
10.1073/pnas.1321248111
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:E3 / E4
页数:2
相关论文
共 5 条
[1]   Generation of C5a in the absence of C3: a new complement activation pathway [J].
Huber-Lang, Markus ;
Sarma, J. Vidya ;
Zetoune, Firas S. ;
Rittirsch, Daniel ;
Neff, Thomas A. ;
McGuire, Stephanie R. ;
Lambris, John D. ;
Warner, Roscoe L. ;
Flierl, Michael A. ;
Hoesel, Laszlo M. ;
Gebhard, Florian ;
Younger, John G. ;
Drouin, Scott M. ;
Wetsel, Rick A. ;
Ward, Peter A. .
NATURE MEDICINE, 2006, 12 (06) :682-687
[2]   Dysregulation of the complement cascade in the hSOD1G93A transgenic mouse model of amyotrophic lateral sclerosis [J].
Lee, John D. ;
Kamaruzaman, Nur A. ;
Fung, Jenny N. T. ;
Taylor, Stephen M. ;
Turner, Bradley J. ;
Atkin, Julie D. ;
Woodruff, Trent M. ;
Noakes, Peter G. .
JOURNAL OF NEUROINFLAMMATION, 2013, 10
[3]   C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice [J].
Lobsiger, Christian S. ;
Boillee, Severine ;
Pozniak, Christine ;
Khan, Amir M. ;
McAlonis-Downes, Melissa ;
Lewcock, Joseph W. ;
Cleveland, Don W. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (46) :E4385-E4392
[4]   Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis [J].
Pavlovski, Dale ;
Thundyil, John ;
Monk, Peter N. ;
Wetsel, Rick A. ;
Taylor, Stephen M. ;
Woodruff, Trent M. .
FASEB JOURNAL, 2012, 26 (09) :3680-3690
[5]   The Complement Factor C5a Contributes to Pathology in a Rat Model of Amyotrophic Lateral Sclerosis [J].
Woodruff, Trent M. ;
Costantini, Kerina J. ;
Crane, James W. ;
Atkin, Julie D. ;
Monk, Peter N. ;
Taylor, Stephen M. ;
Noakes, Peter G. .
JOURNAL OF IMMUNOLOGY, 2008, 181 (12) :8727-8734