New nitric oxide donating 1,2,4-triazole/oxime hybrids: Synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities

被引：41

作者：

Abdel-Aziz, Mohamed ^{[1
]}

Abuo-Rahma, Gamal El-Din A. A. ^{[1
]}

Beshr, Eman A. M. ^{[1
]}

Ali, Taha F. S. ^{[1
]}

机构：

[1] Minia Univ, Dept Med Chem, Fac Pharm, Al Minya 61519, Egypt

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2013年 / 21卷 / 13期

关键词：

1,2,4-Triazole; Nitric oxide donors; Anti-inflammatory; Gastric ulceration; Antiproliferative; BIOLOGICAL EVALUATION; MUCOSAL DAMAGE; DERIVATIVES; CYTOTOXICITY; ULCER; PATHOGENESIS; SUPEROXIDE; DESIGN; INJURY; RAT;

D O I：

10.1016/j.bmc.2013.04.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity. Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin. Calculation of the ulcer indices and histopathological investigation indicated that the prepared NO-donating oximes exhibited less ulcerogenicity compared to their intermediate ketones and indomethacin. The NO-donating oxime 6i revealed significant activity against renal cancer A498 cell lines with 50.52 cell growth inhibition. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3839 / 3849

页数：11

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