The effect of beam-plasma modification of fibrin monomer on its biological properties

被引：6

作者：

Vasil'eva, T. M. ^{[1
]}

Chukhchin, D. G. ^{[2
]}

机构：

[1] Moscow Phys Tech Inst, Dolgoprudnyi 141700, Moscow Oblast, Russia

[2] Archangelsk State Tech Univ, Arkhangelsk 163002, Russia

来源：

HIGH ENERGY CHEMISTRY | 2008年 / 42卷 / 05期

基金：

俄罗斯基础研究基金会;

关键词：

D O I：

10.1134/S0018143908050123

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A change in the antiaggregation activity of fibrin monomer by its modification in helium and water vapor electron-beam plasmas was experimentally studied. It was found that fibrin-monomer modification products reduced the aggregation of platelets by a factor of 1.5 on average and that the acquiring of the antiaggregation properties was accompanied by the degradation of the native protein. It was demonstrated that the degradation process is controllable and products with a desired molecule mass can be obtained via the appropriate choice of the beam-plasma treatment parameters.

引用

页码：404 / 408

页数：5

共 10 条

[1] Validation of cold plasma treatment for protein inactivation: a surface plasmon resonance-based biosensor study [J].

Bernard, C. ;

Leduc, A. ;

Barbeau, J. ;

Saoudi, B. ;

Yahia, L'H ;

De Crescenzo, G. .

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2006, 39 (16) :3470-3478

[2] AGGREGATION OF BLOOD PLATELETS BY ADENOSINE DIPHOSPHATE AND ITS REVERSAL [J].

BORN, GVR .

NATURE, 1962, 194 (4832) :927-&

[3]

Dawson R.M.C, 1986, Data for biochemical research

[4] Chemical and biological characteristics of low-temperature plasma treated ultra-high molecular weight polyethylene for biomedical applications [J].

Klapperich, C ;

Pruitt, L ;

Komvopoulos, K .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2001, 12 (06) :549-556

[5]

SADOVA SF, 2002, 3 MEZHD S TEOR PRIKL, P363

[6] QUANTITATIVE EVALUATION OF INHIBITION OF PLATELET-AGGREGATION BY LOW-MOLECULAR WEIGHT DEGRADATION PRODUCTS OF FIBRINOGEN [J].

SOLUM, NO ;

RIGOLLOT, C ;

BUDZYNSKI, AZ ;

MARDER, VJ .

BRITISH JOURNAL OF HAEMATOLOGY, 1973, 24 (04) :419-+

[7] Modification of biological properties of amino acids by electron-beam plasma treatment [J].

Vasil'ev, M. N. ;

Vasil'eva, T. M. .

HIGH ENERGY CHEMISTRY, 2006, 40 (06) :421-425

[8]

Vasiliev M., 2001, ENCY LOW TEMPERATURE, V11, P436

[9]

VASILIEVA T, 2006, 2 INT WORKSH SUMM SC, P21

[10] Bacterial inactivation using a low-temperature atmospheric plasma brush sustained with argon gas [J].

Yu, Q. S. ;

Huang, C. ;

Hsieh, F. -H. ;

Huff, H. ;

Duan, Yixiang .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2007, 80B (01) :211-219

← 1 →