Mangrove plants are used in medicines, and extracts from mangrove species have proven inhibitory activity against human, animal, and plant pathogens. Endophytic fungi are an important component, are universal, and occur within all know plants, including a broad range of hosts in various ecosystems, and therefore play an important role in the natural environment. Numerous species of mangrove produce bioactive compounds that can control microbial growth. Mangrove extracts can also be the likely sources of mosquito larvicides, antifungal, antiviral, anti-cancer, and anti-diabetic complexes. Mangrove endophytic fungi with promising antioxidant activities that may be useful to humans as novel physiological agents. The present review deals with the endophytic fungi from mangrove plants.