Cardiovascular disease in inflammatory rheumatic diseases

被引:121
作者
Castaneda, Santos [1 ]
Nurmohamed, Michael T. [2 ]
Gonzalez-Gay, Miguel A. [3 ]
机构
[1] Univ Autonoma Madrid, Div Rheumatol, Hosp Princesa, IIS IP, C Diego Leon 62, Madrid 28006, Spain
[2] Vrije Univ Amsterdam Med Ctr, Amsterdam Rheumatol & Immunol Ctr, Reade POB 7057, NL-1007 MB Amsterdam, Netherlands
[3] Univ Cantabria, Epidemiol Genet & Atherosclerosis Res Grp System, Hosp Univ Marques de Valdecilla, IDIVAL,Rheumatol Div, Avda Valdecilla S-N, Santander 39008, Spain
来源
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2016年 / 30卷 / 05期
关键词
Cardiovascular disease; Cardiovascular risk factors; Cardiovascular risk assessment; Rheumatoid arthritis; Spondyloarthritis; Ankylosing spondylitis; Psoriatic arthritis; PSORIATIC-ARTHRITIS PATIENTS; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; HIGH-DENSITY-LIPOPROTEIN; INTIMA-MEDIA THICKNESS; SERUM URIC-ACID; RISK-FACTORS; SUBCLINICAL ATHEROSCLEROSIS; ANKYLOSING-SPONDYLITIS; MYOCARDIAL-INFARCTION;
D O I
10.1016/j.berh.2016.10.006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Chronic inflammatory rheumatic diseases (IRD), including rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis, are prevalent conditions worldwide, with a considerable burden on healthcare systems. They are associated with increased cardiovascular (CV) morbidity and mortality. In this review, we focused on the epidemiology, traditional CV risk factors, genetics, and the link between chronic inflammation, atherosclerosis, and CV disease. Remarkably, patients with IRD have higher vulnerability to atheromatous plaques. The risk of unstable plaques is higher in patients with rheumatoid arthritis than in controls. Active disease is a characteristic ascribed to vulnerability and rupture of plaques and a cause of thrombosis in IRD. Management of CV risk in patients with IRD includes optimal control of disease activity. CV risk stratification by applying risk charts is also essential. Imaging techniques might be useful to determine the actual CV risk of patients with IRD who are included in the category of intermediate or moderate CV risk. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:851 / 869
页数:19
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