Bone and Joint Involvement in Celiac Disease

被引:0
作者
Hoffmanova, I. [1 ]
Sanchez, D. [2 ]
Dzupa, V. [3 ]
机构
[1] Univ Karlovy, Fak Nemocnice Kralovske Vinohrady, Lekarska Fak, Interni Klin 3 2, Prague, Czech Republic
[2] Akad Ceske Republiky, Vvi, Lab Buneone & Mol Imunol, Mikrobiologicky Ustav, Prague, Czech Republic
[3] Univ Karlovy, Fak Nemocnice Kralovske Vinohrady, Lekarska Fak, Ortopedicko Traumatologicka Klin 3, Prague, Czech Republic
关键词
celiac disease; fracture; osteoporosis; osteomalacia; arthritis; arthralgia; gluten-free diet; POPULATION-BASED COHORT; GLUTEN-FREE DIET; MINERAL DENSITY; PRESENTING FEATURE; ADULT PATIENTS; RISK; FRACTURES; ARTHRITIS; EPIDEMIOLOGY; OSTEOPOROSIS;
D O I
暂无
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Celiac disease (gluten-sensitive enteropathy) is currently regarded as a multisystem autoimmune disorder; its clinical signs and symptoms do not involve merely the gastrointestinal tract but are associated with several other medical specialties, including orthopaedics and traumatology. In orthopaedic and trauma patients, celiac disease should be suspected in the following diagnoses; osteomalacia, premenopausal osteoporosis, post-menopausal osteoporosis more severe than expected and refractory to medication, osteoporosis in men under 55 years of age, recurrent bone fractures in the limbs, large joint arthralgia or arthritis of unclear aetiology, erosive spondyloarthropathy particularly in patients with the history of chronic diarrhoea, anaemia or associated autoimmune disorders (type 1 diabetes mellitus or autoimmune thyreopathy), and in women with secondary amenorrhea or early menopause. The orthopaedist or trauma surgeon should be aware of suspected celiac disease in patients who do not respond adequately to the standard treatment of pain related to the musculoskeletal system, in patients with recurrent fractures of the limb bones and in young patients with suspected secondary osteoporosis. With the use of appropriate screening methods, celiac disease as-yet undiagnosed can be revealed. A long-life gluten-free diet in these patients results in the alleviation of metabolic osteopathy and joint and muscle problems, in reduced requirements of analgesic and antiphlogistic drugs as well as in reduced risks of fracture.
引用
收藏
页码:308 / 312
页数:5
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