Genomics and cancer

被引：18
作者：
Onyango, P
机构：
[1] Johns Hopkins Univ, Sch Med, Inst Med Genet, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
来源：
CURRENT OPINION IN ONCOLOGY | 2002年 / 14卷 / 01期
关键词：
D O I：
10.1097/00001622-200201000-00014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Genetic and environmental factors are responsible for the genomic lesions that cause cancer, a complex genetic disease associated with genomic instability. Studies aimed at deciphering the lesions in cancer have focused mainly on one or a few genes, despite the genomic scope of the disease. The recently decoded human DNA sequence is anticipated to foster understanding of human evolution and disease and the role of environment and heredity in the human condition. This review addresses the opportunities and challenges that the availability of the human genome sequence holds for cancer research. (C) 2002 Lippincott Williams Wilkins, Inc.
引用
收藏
页码：79 / 85
页数：7
相关论文
共 78 条
  • [1] *ACS, 1996, CANC FACTS FIG
  • [2] Alaiya AA, 2000, ELECTROPHORESIS, V21, P1210, DOI 10.1002/(SICI)1522-2683(20000401)21:6<1210::AID-ELPS1210>3.3.CO
  • [3] 2-J
  • [4] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    Alizadeh, AA
    Eisen, MB
    Davis, RE
    Ma, C
    Lossos, IS
    Rosenwald, A
    Boldrick, JG
    Sabet, H
    Tran, T
    Yu, X
    Powell, JI
    Yang, LM
    Marti, GE
    Moore, T
    Hudson, J
    Lu, LS
    Lewis, DB
    Tibshirani, R
    Sherlock, G
    Chan, WC
    Greiner, TC
    Weisenburger, DD
    Armitage, JO
    Warnke, R
    Levy, R
    Wilson, W
    Grever, MR
    Byrd, JC
    Botstein, D
    Brown, PO
    Staudt, LM
    [J]. NATURE, 2000, 403 (6769) : 503 - 511
  • [5] Anklesaria P, 2000, CURR OPIN MOL THER, V2, P426
  • [6] SARCOMA GROWTH-FACTOR FROM CONDITIONED MEDIUM OF VIRALLY TRANSFORMED-CELLS IS COMPOSED OF BOTH TYPE-ALPHA AND TYPE-BETA TRANSFORMING GROWTH-FACTORS
    ANZANO, MA
    ROBERTS, AB
    SMITH, JM
    SPORN, MB
    DELARCO, JE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (20): : 6264 - 6268
  • [7] Argani P, 2001, CANCER RES, V61, P4320
  • [8] Bédard ELR, 2001, CANCER-AM CANCER SOC, V91, P2423, DOI 10.1002/1097-0142(20010615)91:12<2423::AID-CNCR1277>3.0.CO
  • [9] 2-1
  • [10] Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach
    Beger, C
    Pierce, LN
    Krüger, M
    Marcusson, EG
    Robbins, JM
    Welcsh, P
    Welch, PJ
    Welte, K
    King, MC
    Barber, JR
    Wong-Staal, F
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (01) : 130 - 135
12345678