Preparation and Drug Release Properties of IBU-loaded Mesoporous Calcium Silicate Hydrate (CSH) spheres

被引：0
|
作者：
Dong, Ya [1 ]
Yuan, Huiwen [1 ]
Ni, Yaru [1 ]
Lu, Chunhua [1 ]
Xu, Zhongzi [1 ]
机构：
[1] Nanjing Univ Technol, State Key Lab Mat Orient Chem Engn, Coll Mat Sci & Engn, Nanjing 210009, Peoples R China
来源：
BIOTECHNOLOGY, CHEMICAL AND MATERIALS ENGINEERING, PTS 1-3 | 2012年 / 393-395卷
关键词：
Calcium silicate hydrate; Mesoporous; drug carrier; DELIVERY SYSTEM; FABRICATION;
D O I：
10.4028/www.scientific.net/AMR.393-395.894
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The novel kind flowerlike mesoporous spheres of calcium silicate hydrate (CaO center dot SiO2 center dot H2O, CSH) have been synthesized by co-precipitation method on based with water/alcohol/calvital/ tetraethyl orthosilicate (TEOS) system. The synthesized CSH were applied as a carrier to study the loaded behaviors of ibuprofen(IBU),was used to investigate the drug loading behavior of the CSH for different times has been also discussed. The drug loading capacities(DLCs) of CSH loaded for 12h has reached 116.78wt.%. The structural, morphological and textural properties were investigated by SEM, FTIR, TG and BET. The results show that it would be a good candidate as drug carrier for bone repair.
引用
收藏
页码：894 / 897
页数：4
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