Hyperglycemia and intramyocardial hemorrhage in patients with ST-segment elevation myocardial infarction

被引:3
作者
Ota, Shingo [1 ]
Nishiguchi, Tsuyoshi [2 ]
Taruya, Akira [1 ]
Tanimoto, Takashi [1 ]
Ino, Yasushi [3 ]
Katayama, Yosuke [3 ]
Ozaki, Yuichi [1 ]
Satogami, Keisuke [1 ]
Tanaka, Atsushi [1 ]
机构
[1] Wakayama Med Univ, Dept Cardiovasc Med, 811-1 Kimiidera, Wakayama 6418510, Japan
[2] Wakaura Cent Hosp, Dept Internal Med, Wakayama, Japan
[3] Shingu Municipal Med Ctr, Dept Cardiovasc Med, Wakayama, Japan
关键词
Hyperglycemia; Intramyocardial hemorrhage; ST-segment elevation myocardial infarction; Matrix metalloproteinase-9; NO-REFLOW PHENOMENON; CARDIAC MAGNETIC-RESONANCE; MICROVASCULAR OBSTRUCTION; ASSOCIATION; OCCLUSION; DEATH; CORE; RISK;
D O I
10.1016/j.jjcc.2022.06.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Hyperglycemia at admission and intramyocardial hemorrhage (IMH) are associated with poor prog-nosis in patients with ST-segment elevation myocardial infarction (STEMI). Little is known about the relationship between glucose levels at admission and IMH. The association between matrix metalloproteinase-9 (MMP-9), which plays an important role in the development of IMH, and hyperglycemia is also unknown. This study aimed to investigate the relationship between hyperglycemia at admission and IMH in patients with STEMI. Methods: We enrolled 174 patients with first STEMI who underwent primary percutaneous coronary interven-tion (PCI) and cardiovascular magnetic resonance (CMR) imaging. T2-weighted imaging and late gadolinium enhancement (LGE)-CMR were performed to detect IMH and microvascular obstruction (MVO), respectively. Two patient groups were created: IMH group and non-IMH group. MMP-9 levels were measured in the culprit coronary arteries of 13 patients. Results: Glucose level at admission and the value of glycosylated hemoglobin were higher in the IMH group than in the non-IMH group [IMH group vs. non-IMH group; 208.5 (157.8-300.5) mg/dL vs. 157.0 (128.8-204.3) mg/dL, p < 0.001, and 6.2 (5.7-7.5) % vs. 5.8 (5.4-6.6) %, p = 0.030, respectively]. A multivariable logistic regression analysis revealed that only admission glucose level was an independent predictor of IMH (OR: 1.012; 95 % CI: 1.005-1.020, p = 0.001). The MMP-9 levels in patients with IMH were higher than those in patients without IMH [256.0 (161.0-396.0) ng/mL vs. 73.5 (49.5-131.0) ng/mL, p = 0.040]. There was a moderate positive corre-lation between glucose levels at admission and MMP-9 levels (r = 0.600, p = 0.030). Conclusions: Hyperglycemia at admission is associated with the occurrence of IMH in patients with STEMI. (C) 2022 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:456 / 461
页数:6
相关论文
共 31 条
[1]   Predictors of Intramyocardial Hemorrhage After Reperfused ST-Segment Elevation Myocardial Infarction [J].
Amier, Raquel P. ;
Tijssen, Ruben Y. G. ;
Teunissen, Paul F. A. ;
Fernandez-Jimenez, Rodrigo ;
Pizarro, Gonzalo ;
Garcia-Lunar, Ines ;
Bastante, Teresa ;
van de Ven, Peter M. ;
Beek, Aernout M. ;
Smulders, Martijn W. ;
Bekkers, Sebastiaan C. A. M. ;
van Royen, Niels ;
Ibanez, Borja ;
Nijveldt, Robin .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (08)
[2]  
[Anonymous], 1994, Circulation, V89, P1545
[3]   DEMONSTRATION OF THE NO-REFLOW PHENOMENON BY DIGITAL CORONARY ARTERIOGRAPHY [J].
BATES, ER ;
KRELL, MJ ;
DEAN, EN ;
ONEILL, WW ;
VOGEL, RA .
AMERICAN JOURNAL OF CARDIOLOGY, 1986, 57 (01) :177-178
[4]   Intramyocardial hemorrhage and microvascular obstruction after primary percutaneous coronary intervention [J].
Beek, A. M. ;
Nijveldt, R. ;
van Rossum, A. C. .
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 2010, 26 (01) :49-55
[5]   Clinical implications of microvascular obstruction and intramyocardial haemorrhage in acute myocardial infarction using cardiovascular magnetic resonance imaging [J].
Bekkers, Sebastiaan C. A. M. ;
Smulders, Martijn W. ;
Passos, Valeria Lima ;
Leiner, Tim ;
Waltenberger, Johannes ;
Gorgels, Anton P. M. ;
Schalla, Simon .
EUROPEAN RADIOLOGY, 2010, 20 (11) :2572-2578
[6]   Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview [J].
Capes, SE ;
Hunt, D ;
Malmberg, K ;
Gerstein, HC .
LANCET, 2000, 355 (9206) :773-778
[7]   Temporal Evolution of Myocardial Hemorrhage and Edema in Patients After Acute ST-Segment Elevation Myocardial Infarction: Pathophysiological Insights and Clinical Implications [J].
Carrick, David ;
Haig, Caroline ;
Ahmed, Nadeem ;
Rauhalammi, Samuli ;
Clerfond, Guillaume ;
Carberry, Jaclyn ;
Mordi, Ify ;
McEntegart, Margaret ;
Petrie, Mark C. ;
Eteiba, Hany ;
Hood, Stuart ;
Watkins, Stuart ;
Lindsay, M. Mitchell ;
Mahrous, Ahmed ;
Welsh, Paul ;
Sattar, Naveed ;
Ford, Ian ;
Oldroyd, Keith G. ;
Radjenovic, Aleksandra ;
Berry, Colin .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2016, 5 (02)
[8]   Myocardial Hemorrhage After Acute Reperfused ST-Segment-Elevation Myocardial Infarction Relation to Microvascular Obstruction and Prognostic Significance [J].
Carrick, David ;
Haig, Caroline ;
Ahmed, Nadeem ;
McEntegart, Margaret ;
Petrie, Mark C. ;
Eteiba, Hany ;
Hood, Stuart ;
Watkins, Stuart ;
Lindsay, M. Mitchell ;
Davie, Andrew ;
Mahrous, Ahmed ;
Mordi, Ify ;
Rauhalammi, Samuli ;
Sattar, Naveed ;
Welsh, Paul ;
Radjenovic, Aleksandra ;
Ford, Ian ;
Oldroyd, Keith G. ;
Berry, Colin .
CIRCULATION-CARDIOVASCULAR IMAGING, 2016, 9 (01)
[9]   Prognostic Value and Determinants of a Hypointense Infarct Core in T2-Weighted Cardiac Magnetic Resonance in Acute Reperfused ST-Elevation-Myocardial Infarction [J].
Eitel, Ingo ;
Kubusch, Konrad ;
Strohm, Oliver ;
Desch, Steffen ;
Mikami, Yoko ;
de Waha, Suzanne ;
Gutberlet, Matthias ;
Schuler, Gerhard ;
Friedrich, Matthias G. ;
Thiele, Holger .
CIRCULATION-CARDIOVASCULAR IMAGING, 2011, 4 (04) :354-362
[10]   Cardiovascular MR T2-STIR imaging does not discriminate between intramyocardial haemorrhage and microvascular obstruction during the subacute phase of a reperfused myocardial infarction [J].
Hansen, Esben Sovso Szocska ;
Pedersen, Steen Fjord ;
Pedersen, Steen Bonlokke ;
Kjaergaard, Uffe ;
Schmidt, Nikolaj Hjort ;
Botker, Hans Erik ;
Kim, Won Yong .
OPEN HEART, 2016, 3 (01)