Lung cancer stem cells

被引：27
|
作者：
Pine, Sharon R. [1 ]
Marshall, Blair [2 ]
Varticovski, Lyuba [1 ]
机构：
[1] NCI, Ctr Canc Res, NIH, LHC, Bethesda, MD 20892 USA
[2] Georgetown Univ, Washington, DC USA
来源：
DISEASE MARKERS | 2008年 / 24卷 / 4-5期
关键词：
ABC transporters; drug resistance; hedgehog; notch; non-small cell lung cancer; side population; small cell lung cancer; stem cells; Wnt;
D O I：
10.1155/2008/396281
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic characteristics including high proliferative capacity, multipotent differentiation, drug resistance and long lifespan relative to other cells. Stem cell signaling and differentiation pathways are maintained within distinct cancer types, and destabilization of this machinery may participate in maintenance of cancer stem cells. Characterization of lung cancer stem cells is an area of active research and is critical for developing novel therapies. This review summarizes the current knowledge on stem cell signaling pathways and cell markers used to identify the lung cancer stem cells.
引用
收藏
页码：257 / 266
页数：10
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