Lung cancer stem cells

被引：27
|
作者：
Pine, Sharon R. [1 ]
Marshall, Blair [2 ]
Varticovski, Lyuba [1 ]
机构：
[1] NCI, Ctr Canc Res, NIH, LHC, Bethesda, MD 20892 USA
[2] Georgetown Univ, Washington, DC USA
来源：
DISEASE MARKERS | 2008年 / 24卷 / 4-5期
关键词：
ABC transporters; drug resistance; hedgehog; notch; non-small cell lung cancer; side population; small cell lung cancer; stem cells; Wnt;
D O I：
10.1155/2008/396281
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic characteristics including high proliferative capacity, multipotent differentiation, drug resistance and long lifespan relative to other cells. Stem cell signaling and differentiation pathways are maintained within distinct cancer types, and destabilization of this machinery may participate in maintenance of cancer stem cells. Characterization of lung cancer stem cells is an area of active research and is critical for developing novel therapies. This review summarizes the current knowledge on stem cell signaling pathways and cell markers used to identify the lung cancer stem cells.
引用
收藏
页码：257 / 266
页数：10
相关论文
共 50 条
  • [31] Lung Cancer Stem Cells and Cancer Stem Cell-targeting Natural Compounds
    Maiuthed, Arnatchai
    Chantarawong, Wipa
    Chanvorachote, Pithi
    ANTICANCER RESEARCH, 2018, 38 (07) : 3797 - 3809
  • [32] Regulatory mechanisms of microRNAs in lung cancer stem cells
    Fan, Tao
    Wang, Wei
    Zhang, Boyou
    Xu, Yao
    Chen, Lei
    Pan, Shize
    Hu, Hao
    Geng, Qing
    SPRINGERPLUS, 2016, 5
  • [33] Lung cancer stem cells-characteristics, phenotype
    Hardavella, Georgia
    George, Rachel
    Sethi, Tariq
    TRANSLATIONAL LUNG CANCER RESEARCH, 2016, 5 (03) : 272 - 279
  • [34] Evidence for tumor initiating stem cells in lung cancer
    Zhang, Wen Cai
    Yang, He
    Soh, Boon Seng
    Sun, Li Li
    Chin, Tan Min
    Lim, Elaine Hsuen
    Lim, Bing
    CANCER RESEARCH, 2011, 71
  • [35] Lung cancer stem cells: Identification and translation to the clinic
    Minna, John D.
    Sullivan, James P.
    Spinola, Monica
    Larsen, Jill
    Gao, Boning
    Frink, Robin
    Huang, Chunxian
    Delgado, Oliver
    Dodge, Michael
    Schuster, Katja
    Scaglioni, Pier P.
    Yuan, Ping
    Raso, Gabriela
    Yang, Fei
    Sun, Sophie
    Schiller, Joan
    Gazdar, Adi F.
    Shay, Jerry
    Wistuba, Ignacio I.
    JOURNAL OF THORACIC ONCOLOGY, 2010, 5 (06) : S215 - S216
  • [36] Could stem cells be used to treat lung cancer?
    Crisp, Alisa
    LUNG CANCER MANAGEMENT, 2013, 2 (03) : 182 - 183
  • [37] Lung cancer stem cells: a biological and clinical perspective
    Koren, Ana
    Motaln, Helena
    Cufer, Tanja
    CELLULAR ONCOLOGY, 2013, 36 (04) : 265 - 275
  • [38] Lung Cancer Stem Cells and Implications for Future Therapeutics
    Wang, Jing
    Li, Ze-hong
    White, James
    Zhang, Lin-bo
    CELL BIOCHEMISTRY AND BIOPHYSICS, 2014, 69 (03) : 389 - 398
  • [39] Aptamers as a Tool to Detect Lung Cancer Stem Cells
    Nascimento, Isis
    Mavri, Jan
    Smuc, Tina
    Nery, Arthur
    Peterka, Matjaz
    Ulrich, Henning
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (01) : S1156 - S1156
  • [40] Lung Cancer Stem Cells and Implications for Future Therapeutics
    Jing Wang
    Ze-hong Li
    James White
    Lin-bo Zhang
    Cell Biochemistry and Biophysics, 2014, 69 : 389 - 398
12345