Generation of an UGI library of phosphate mimic-containing compounds and identification of novel dual specific phosphatase inhibitors

被引：30

作者：

Bergnes, G

Gilliam, CL

Boisclair, MD

Blanchard, JL

Blake, KV

Epstein, DM

Pal, K

机构：

[1] Mitotix Inc, Dept Med Chem, Cambridge, MA 02139 USA

[2] Mitotix Inc, Dept Biomol Screening, Cambridge, MA 02139 USA

[3] Mitotix Inc, Dept Biochem, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(99)00497-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The four-component Ugi reaction was utilized to prepare a library of dipeptidic compounds in order to explore the binding requirements of the key cell cycle phosphatase, Cdc25. Several phosphate surrogates were incorporated into the Ugi product to mimic either the mono- or bis-phospholylated substrate. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：2849 / 2854

页数：6

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