The challenge of pancreatic cancer therapy and novel treatment strategy using engineered mesenchymal stem cells

被引：26

作者：

Moniri, M. R. ^{[1
]}

Dai, L-J ^{[1
,2
]}

Warnock, G. L. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Surg, Vancouver, BC V5Z 1L8, Canada

[2] Hubei Univ Med, Taihe Hosp, Hubei Key Lab Stem Cell Res, Shiyan, Peoples R China

来源：

CANCER GENE THERAPY | 2014年 / 21卷 / 01期

关键词：

pancreatic cancer; mesenchymal stem cells; MARROW STROMAL CELLS; BONE-MARROW; IN-VITRO; PTEN EXPRESSION; GROWTH-FACTOR; PROGENITOR CELLS; BETA-CATENIN; TUMOR STROMA; T-CELLS; INTRAVENOUS DELIVERY;

D O I：

10.1038/cgt.2013.83

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mesenchymal stem cells (MSCs) have attracted significant attention in cancer research as a result of their accessibility, tumor-oriented homing capacity, and the feasibility of auto-transplantation. This review provides a comprehensive overview of current challenges in pancreatic cancer therapy, and we propose a novel strategy for using MSCs as means of delivering anticancer genes to the site of pancreas. We aim to provide a practical platform for the development of MSC-based therapy for pancreatic cancer.

引用

页码：12 / 23

页数：12

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