Development of a Collagen Hydrogel with High Mechanical Strength by a Simple Orientation Method for Triple-helix

被引：5

作者：

Hongo, Chizuru ^{[1
,2
]}

Matsusaki, Michiya ^{[1
,2
]}

Nishida, Kohji ^{[2
,3
]}

Akashi, Mitsuru ^{[1
,2
]}

机构：

[1] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

[2] Osaka Univ, 21st Century COE Program, Ctr Integrated Cell & Tissue Regulat, Suita, Osaka 5650871, Japan

[3] Tohoku Univ, Sch Med, Dept Ophthalmol, Aoba Ku, Sendai, Miyagi 9808574, Japan

来源：

CHEMISTRY LETTERS | 2008年 / 37卷 / 12期

关键词：

D O I：

10.1246/cl.2008.1254

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Collagen hydrogels with oriented triple-helix were fabricated simply via the axial orientation of a dense collagen solution onto a glass plate and cross-linking. The orientation of the collagen triple-helix in the gels was clearly confirmed by X-ray diffraction measurements. The tensile strength of the oriented collagen gels in parallel was twofold higher than that of non-oriented gels as a control. Our collagen gels with oriented triple-helix can be. useful as novel scaffolds in the tissue engineering field.

引用

收藏

页码：1254 / 1255

页数：2

相关论文

共 8 条

[1] Thin films of oriented collagen fibrils for cell motility studies [J].

Amyot, Franck ;

Small, Alex ;

Boukari, Hacene ;

Sackett, Dan ;

Elliott, John ;

McDaniel, Dennis ;

Plant, Anne ;

Gandjbakhche, Amir .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2008, 86B (02) :438-443

[2] Flow and magnetic field induced collagen alignment [J].

Guo, Cheng ;

Kaufman, Laura J. .

BIOMATERIALS, 2007, 28 (06) :1105-1114

[3] Building collagen molecules, fibrils, and suprafibrillar structures [J].

Hulmes, DJS .

JOURNAL OF STRUCTURAL BIOLOGY, 2002, 137 (1-2) :2-10

[4] A simple, cross-linked collagen tissue substitute for corneal implantation [J].

Liu, Yuwen ;

Gan, Lisha ;

Carlsson, David J. ;

Fagerholm, Per ;

Lagali, Neil ;

Watsky, Mitchell A. ;

Munger, Rejean ;

Hodge, William G. ;

Priest, David ;

Griffith, May .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2006, 47 (05) :1869-1875

[5] X-ray diffraction study into the effects of liming on the structure of collagen [J].

Maxwell, Clark A. ;

Wess, Tim J. ;

Kennedy, Craig J. .

BIOMACROMOLECULES, 2006, 7 (08) :2321-2326

[6] Revision of collagen molecular structure [J].

Okuyama, K ;

Xu, XZ ;

Iguchi, M ;

Noguchi, K .

BIOPOLYMERS, 2006, 84 (02) :181-191

[7] Microfibrillar structure of type I collagen in situ [J].

Orgel, Joseph P. R. O. ;

Irving, Thomas C. ;

Miller, Andrew ;

Wess, Tim J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (24) :9001-9005

[8] Orthogonal scaffold of magnetically aligned collagen lamellae for corneal stroma reconstruction [J].

Torbet, Jim ;

Malbouyres, Marilyne ;

Builles, Nicolas ;

Justin, Virginie ;

Roulet, Muriel ;

Damour, Odile ;

Oldberg, Ake ;

Ruggieo, Florence ;

Hulmes, David J. S. .

BIOMATERIALS, 2007, 28 (29) :4268-4276