Caveolin-1 polymorphisms in patients with severe obstructive sleep apnea

被引：3
作者：
Asker, Selvi [1 ]
Taspinar, Mehmet [2 ]
Koyun, Hasan [3 ]
Ozbay, Bulent [4 ]
Arisoy, Ahmet [1 ]
机构：
[1] Yuzuncu Yil Univ, Dept Chest Dis, Sch Med, Van, Turkey
[2] Yuzuncu Yil Univ, Dept Med Biol, Sch Med, Van, Turkey
[3] Yuzuncu Yil Univ, Fac Agr, Biometry & Genet Unit, Van, Turkey
[4] Mugla Sitki Kocman Univ, Sch Med, Dept Chest Dis, Mugla, Turkey
来源：
BIOMARKERS | 2017年 / 22卷 / 01期
关键词：
G14713A; genotype; polymorphic variant; T29107A; IN-VIVO; CHILDREN;
D O I：
10.1080/1354750X.2016.1204007
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Objective: To investigate the associations of G14713A and T29107A polymorphic variants of Caveolin-1 with severe obstructive sleep apnea (OSA). Materials and methods: This study was performed on 86 severe OSA patients and 86 controls. Genotyping was performed to investigate the association of G14713A and T29107A polymorphisms of Caveolin-1 with severe OSA. Results: The distribution of genotypes of T29107A was significantly different between controls and OSA patients with a higher proportion of TT carriers in the OSA group. Conclusion: T29107A-specific genotype of Caveolin-1 may be linked with severe OSA pathogenesis.
引用
收藏
页码：77 / 80
页数：4
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