Epithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compounds

被引：114
作者：
Samatov, Timur R. [1 ]
Tonevitsky, Alexander G. [2 ,3 ]
Schumacher, Udo [4 ]
机构：
[1] SRC Bioclin, Moscow 115088, Russia
[2] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia
[3] PA Hertsen Moscow Res Oncol Inst, Moscow 125284, Russia
[4] Univ Med Ctr Hamburg Eppendorf, Univ Canc Ctr, Dept Anat & Expt Morphol, D-20246 Hamburg, Germany
来源：
MOLECULAR CANCER | 2013年 / 12卷
关键词：
Alternative splicing; Cell adhesion molecules; Epithelial-mesenchymal transition; Metastatic cascade; Non-coding RNAs; Small molecule compounds; Transcription factors; CIRCULATING TUMOR-CELLS; BREAST-CANCER; E-CADHERIN; MIR-200; FAMILY; TRANSCRIPTION FACTORS; GENE-EXPRESSION; EMT; INVASION; BLADDER; CONTRIBUTES;
D O I：
10.1186/1476-4598-12-107
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and metastases formation during malignant progression. This review focuses on transcriptional regulation, non-coding RNAs, alternative splicing events and cell adhesion molecules regulation during EMT. Additionally, we summarize the knowledge with regard to the small potentially druggable molecules capable of modulating EMT for cancer therapy.
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页数：12
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