Hydrogels containing metallic glass sub-micron wires for regulating skeletal muscle cell behaviour

被引：27

作者：

Ahadian, Samad ^{[1
]}

Sadeghian, Ramin Banan ^{[1
]}

Yaginuma, Shin ^{[1
]}

Ramon-Azcon, Javier ^{[1
]}

Nashimoto, Yuji ^{[2
]}

Liang, Xiaobin ^{[1
]}

Bae, Hojae ^{[3
]}

Nakajima, Ken ^{[1
]}

Shiku, Hitoshi ^{[2
]}

Matsue, Tomokazu ^{[1
,2
]}

Nakayama, Koji S. ^{[1
]}

Khademhosseini, Ali ^{[1
,3
,4
,5
,6
,7
]}

机构：

[1] Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan

[2] Tohoku Univ, Grad Sch Environm Studies, Sendai, Miyagi 9808579, Japan

[3] Konkuk Univ, Dept Bioind Technol, Coll Anim Biosci & Technol, Seoul 143701, South Korea

[4] Harvard Univ, Brigham & Womens Hosp, Biomat Innovat Res Ctr, Div Biomed Engn,Dept Med,Med Sch, Boston, MA 02139 USA

[5] MIT, Harvard Massachusetts Inst Technol, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[6] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

[7] King Abdulaziz Univ, Dept Phys, Fac Sci, Jeddah 21569, Saudi Arabia

来源：

BIOMATERIALS SCIENCE | 2015年 / 3卷 / 11期

关键词：

NONINVASIVE MEASUREMENT; ELECTRICAL-STIMULATION; RESPIRATORY ACTIVITY; SCAFFOLDS; CORROSION; GRAPHENE; DIFFERENTIATION; PROLIFERATION; GENERATION; MORPHOLOGY;

D O I：

10.1039/c5bm00215j

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Hydrogels with tunable electrical and mechanical properties have a wide range of biological applications in tissue engineering, biosensing, and biorobotics. In this work, palladium-based metallic glass sub-micron wires (PdMGSMWs) were employed to enhance the conductivity and mechanical strength of gelatin methacryloyl (GelMA) gels. The values of electrical resistivity and stiffness of hybrid GelMA-PdMGSMW hydrogels were varied by the concentration of the sub-micron wires in the gels. Compared with pristine GelMA gels, hybrid GelMA-PdMGSMW gels were more efficient in regulating adhesion and spreading of C2C12 myoblasts. Formation, contractility, and metabolic activity of C2C12 myotubes in GelMA hydrogels also increased upon inclusion of the PdMGSMWs and applying electrical stimulation. The latter phenomenon is likely because of the electrical conductivity of hybrid GelMA gels.

引用

页码：1449 / 1458

页数：10

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