The increment of anti-ORP150 autoantibody in initial stages of atheroma in high-fat diet fed mice

被引：6

作者：

Kobayashi, T ^{[1
]}

Yura, T ^{[1
]}

Yanagi, H ^{[1
]}

机构：

[1] HSP Res Inst, Shimogyo Ku, Kyoto 6008813, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2002年 / 64卷 / 02期

关键词：

atheroma; autoantigen; ORP150;

D O I：

10.1292/jvms.64.177

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Expression of 150 kda oxygen-regulated protein, ORP150, was examined in the atheromatous lesions on aortic valves in high-fat diet fed mice. Immunohistochemical staining revealed that ORP150 was expressed on the surface of plaque and was co-localized with phagocytes bearing Mac-3, a mouse macrophage differentiation antigen. These findings suggest that ORP150 is involved in the development of the atheromatous plaque. Titer of autoantibody against ORP150 was gradually elevated in parallel with the length of period of high-fat diet feeding. These results suggest that the deposition of immunocomplex toward ORP150 antigen is involved in atheromatous plaque progression.

引用

收藏

页码：177 / 180

页数：4

相关论文

共 16 条

[1] Evidence of hypoxic areas within the arterial wall in vivo [J].

Björnheden, T ;

Levin, M ;

Evaldsson, M ;

Wiklund, O .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (04) :870-876

[2]

DRESEL HA, 1985, ARZNEIMITTEL-FORSCH, V35-2, P1936

[3]

HANSSON GK, 1994, BASIC RES CARDIOL, V89, P41

[4] ENHANCED MACROPHAGE DEGRADATION OF LOW-DENSITY LIPOPROTEIN PREVIOUSLY INCUBATED WITH CULTURED ENDOTHELIAL-CELLS - RECOGNITION BY RECEPTORS FOR ACETYLATED LOW-DENSITY LIPOPROTEINS [J].

HENRIKSEN, T ;

MAHONEY, EM ;

STEINBERG, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10) :6499-6503

[5]

HO MK, 1983, J BIOL CHEM, V258, P636

[6] LDL hypercholesterolemia is associated with accumulation of oxidized LDL, atherosclerotic plaque growth, and compensatory vessel enlargement in coronary arteries of miniature pigs [J].

Holvoet, P ;

Theilmeier, G ;

Shivalkar, B ;

Flameng, W ;

Collen, D .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (03) :415-422

[7] Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150 [J].

Ikeda, J ;

Kaneda, S ;

Kuwabara, K ;

Ogawa, S ;

Kobayashi, T ;

Matsumoto, M ;

Yura, T ;

Yanagi, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 230 (01) :94-99

[8] THE 2-RECEPTOR MODEL OF LIPOPROTEIN CLEARANCE - TESTS OF THE HYPOTHESIS IN KNOCKOUT MICE LACKING THE LOW-DENSITY-LIPOPROTEIN RECEPTOR, APOLIPOPROTEIN-E, OR BOTH PROTEINS [J].

ISHIBASHI, S ;

HERZ, J ;

MAEDA, N ;

GOLDSTEIN, JL ;

BROWN, MS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (10) :4431-4435

[9] Abundant expression of 150-kDa oxygen-regulated protein in mouse pancreatic beta cells is correlated with insulin secretion [J].

Kobayashi, T ;

Ogawa, S ;

Yura, T ;

Yanagi, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 267 (03) :831-837

[10]

Kuwabara K, 1996, J BIOL CHEM, V271, P5025