Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles

被引：31

作者：

Aksenov, Alexander V. ^{[1
]}

Khamraev, Vladislav ^{[1
]}

Aksenov, Nicolai A. ^{[1
]}

Kirilov, Nikita K. ^{[1
]}

Domenyuk, Dmitriy A. ^{[2
]}

Zelensky, Vladimir A. ^{[2
]}

Rubin, Michael ^{[1
,3
]}

机构：

[1] North Caucasus Fed Univ, Dept Chem, 1a Pushkin St, Stavropol 355009, Russia

[2] Stavropol State Med Univ, Dept Gen Practice Dent & Child Dent, 310 Mira St, Stavropol 355017, Russia

[3] Univ Kansas, Dept Chem, 1567 Irving Hill Rd, Lawrence, KS 66045 USA

来源：

RSC ADVANCES | 2019年 / 9卷 / 12期

基金：

俄罗斯基础研究基金会;

关键词：

ONE-POT SYNTHESIS; BENZOXAZOLES; DESIGN; NITRO;

D O I：

10.1039/c9ra00976k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel methodology for general and chemoselective preparation of non-symmetric 1,3,4-oxadiazoles is developed. This unusual reaction proceeds via polyphosphoric acid-assisted activation of nitroalkanes towards nucleophilic attack with acylhydrazides.

引用

页码：6636 / 6642

页数：7

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