Triterpene based compounds with potent anti-maturation activity against HIV-1

被引：20

作者：

Gerrish, David ^{[1
]}

Kim, In Chul ^{[1
]}

Kumar, Dange V. ^{[1
]}

Austin, Harry ^{[1
]}

Garrus, Jennifer E. ^{[1
]}

Baichwal, Vijay ^{[1
]}

Saunders, Michael ^{[1
]}

McKinnon, Rena S. ^{[1
]}

Anderson, Mark B. ^{[1
]}

Carlson, Robert ^{[1
]}

Arranz-Plaza, Esther ^{[1
]}

Yager, Kraig M. ^{[1
]}

机构：

[1] Myriad Pharmaceut Inc, Salt Lake City, UT 84108 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 24期

关键词：

Betulinic acid; Triterpene; HIV-1; Maturation inhibitor; Anti-viral;

D O I：

10.1016/j.bmcl.2008.10.098

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Efforts towards developing orally bioavailable HIV-1 maturation inhibitors starting from betulinic acid 1 are described. SAR resulted in improved potency, physicochemical properties, and enhanced oral absorption in rats. (C) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：6971 / 6380

页数：4

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