Novel roles of the unfolded protein response in the control of tumor development and aggressiveness

被引：52

作者：

Dejeans, Nicolas ^{[1
,2
]}

Barroso, Kim ^{[1
,2
,3
,4
,5
]}

Fernandez-Zapico, Martin E. ^{[3
]}

Samali, Afshin ^{[6
]}

Chevet, Eric ^{[1
,2
,4
,5
]}

机构：

[1] INSERM, UMR 1053, Team Endoplasm Reticulum Stress & Canc, F-33000 Bordeaux, France

[2] Univ Bordeaux, F-33000 Bordeaux, France

[3] Mayo Clin, Div Oncol Res, Schulze Ctr Novel Therapeut, Rochester, MN USA

[4] Univ Rennes 1, ER440, Oncogenesis, Stress,Signaling, F-35000 Rennes, France

[5] Ctr Lutte Canc Eugene Marquis, Rennes, France

[6] NUI Galway, Sch Nat Sci, Apoptosis Res Ctr, Galway, Ireland

来源：

SEMINARS IN CANCER BIOLOGY | 2015年 / 33卷

关键词：

Endoplasmic reticulum; Cancer; Stress; Tumor; EMT; ENDOPLASMIC-RETICULUM STRESS; TO-MESENCHYMAL TRANSITION; NEGATIVE BREAST-CANCER; ER STRESS; TRANSCRIPTION FACTOR; MALIGNANT PROGRESSION; CELLULAR PHYSIOLOGY; EPITHELIAL-CELLS; IN-VIVO; KINASE;

D O I：

10.1016/j.semcancer.2015.04.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The hallmarks of cancer currently define the molecular mechanisms responsible for conferring specific tumor phenotypes. Recently, these characteristics were also connected to the status of the secretory pathway, thereby linking the functionality of this cellular machinery to the acquisition of cancer cell features. The secretory pathway ensures the biogenesis of proteins that are membrane-bound or secreted into the extracellular milieu and can control its own homeostasis through an adaptive signaling pathway named the unfolded protein response (UPR). In the present review, we discuss the specific features of the UPR in various tumor types and the impact of the selective activation of this pathway on cell transformation, tumor development and aggressiveness. (C) 2015 Elsevier Ltd. All rights reserved.

引用

收藏

页码：67 / 73

页数：7

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