MRI and neuropsychological improvement in Huntington disease following ethyl-EPA treatment

被引：78

作者：

Puri, BK

Bydder, GM

Counsell, SJ

Corridan, BJ

Richardson, AJ

Hajnal, JV

Appel, C

McKee, HM

Vaddadi, KS

Horrobin, DF

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, MRC,Clin Sci Ctr,Magnet Resonance Unit, London W12 0HS, England

[2] Univ London Imperial Coll Sci Technol & Med, Sch Med, London, England

[3] Ealing Hammersmith & Fulham Mental Hlth NHS Trust, London, England

[4] Laxdale Res, Stirling, Scotland

[5] Monash Med Ctr, Dept Psychiat, Clayton, Vic 3168, Australia

来源：

NEUROREPORT | 2002年 / 13卷 / 01期

关键词：

EPA; ethyl eicosapentaenoate; Huntington disease; motor system; MRI; subvoxel registration;

D O I：

10.1097/00001756-200201210-00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A 6-month randomized, placebo-controlled pilot study of the ethyl-ester of eicosapentaenoic acid (ethyl-EPA) was carried out in seven in-patients with advanced (stage III) Huntington's disease (three on ethyl-EPA, four on placebo; no significant difference in age or sex between the groups). After 6 months all the patients treated with ethyl-EPA improved on the orofacial component of the Unified Huntington's Disease Rating Scale while all the patients on placebo deteriorated on this scale (p < 0.03). Following subvoxel registration of follow-up 3D MRI brain scans with baseline scans, subtraction images showed that while the placebo was associated with progressive cerebral atrophy, the ethyl-EPA was associated with a reverse process. We conclude that treatment with ethyl-EPA is associated with beneficial motor and MRI changes. NeuroReport 13;123-126 (C) 2002 Lippincott Williams & Wilkins.

引用

页码：123 / 126

页数：4

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