Structure elucidation of indole-indoline type alkaloids: A retrospective account from the point of view of current NMR and MS technology

被引：19

作者：

Beni, Zoltan ^{[1
]}

Hada, Viktor ^{[2
]}

Dubrovay, Zsofia ^{[1
]}

Szantay, Csaba, Jr. ^{[1
]}

机构：

[1] Chem Works Gedeon Richter Plc, API Res & Dev Spectroscop Res, NMR Lab, H-1475 Budapest 10, Hungary

[2] Chem Works Gedeon Richter Plc, API Res & Dev Spectroscop Res, MS Lab, H-1475 Budapest 10, Hungary

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2012年 / 69卷

关键词：

Bisindole; Structure determination; NMR; MS; Historical scope; INDIRECT COVARIANCE NMR; DIMERIC CATHARANTHUS ALKALOIDS; NATURALLY-OCCURRING SUBSTANCES; VINCA ALKALOIDS; DEGRADATION-PRODUCTS; IN-VITRO; MASS-SPECTRA; LEUROCRISTINE VINCRISTINE; METABOLIC TRANSFORMATIONS; CHEMICAL CHARACTERIZATION;

D O I：

10.1016/j.jpba.2012.02.015

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this review our aim is to look back on how the structure elucidation of bisindoles, especially with focus placed on vinblastine and vincristine analogues, has evolved alongside with the development of MS and NMR over the last 60 years from the perspective of our present-day use of state-of-the-art MS and NMR instrumentation and on the basis of our own accumulated views and experience in the field. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：106 / 124

页数：19

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