Conjugation of curcumin with PVP capped gold nanoparticles for improving bioavailability

被引：118

作者：

Gangwar, Rajesh K. ^{[1
]}

Dhumale, Vinayak A. ^{[1
]}

Kumari, Dimple ^{[2
]}

Nakate, Umesh T. ^{[1
]}

Gosavi, S. W. ^{[3
]}

Sharma, Rishi B. ^{[4
]}

Kale, S. N. ^{[1
]}

Datar, Suwarna ^{[1
]}

机构：

[1] Def Inst Adv Technol DU, Dept Appl Phys, Pune 411025, Maharashtra, India

[2] Def Inst Adv Technol DU, Dept Appl Chem, Pune 411025, Maharashtra, India

[3] Univ Pune, Dept Phys, Pune 411007, Maharashtra, India

[4] DRDO Bhawan, DOP, New Delhi 110105, India

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2012年 / 32卷 / 08期

关键词：

Curcumin; Gold nanoparticles; Bioavailability; BIOLOGICAL-ACTIVITIES; FORMULATION; DELIVERY; SIZE;

D O I：

10.1016/j.msec.2012.07.022

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Curcumin, a natural polyphenolic compound, has astounding therapeutic applications but lacks in bioavailability mainly due to its poor solubility in water. Polyvinyl pyrrolidone (PVP) which is a proven drug carrier has been used to facilitate the conjugation of curcumin with gold nanoparticles and to improve the solubility of curcumin in water. In this conjugate diaryl heptanoid chromophore group of curcumin which is a much needed group in biomedical applications remains intact as observed from FTIR and UV-vis spectroscopy analysis. The work shows good promise for such conjugates as therapeutic-cum-imaging materials in biomedical field. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：2659 / 2663

页数：5

共 34 条

[21] Chemical studies on antioxidant mechanism of curcuminoid: Analysis of radical reaction products from curcumin [J].

Masuda, T ;

Hidaka, K ;

Shinohara, A ;

Maekawa, T ;

Takeda, Y ;

Yamaguchi, H .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1999, 47 (01) :71-77

[22] Curcumin-decorated nanoliposomes with very high affinity for amyloid-β1-42 peptide [J].

Mourtas, Spyridon ;

Canovi, Mara ;

Zona, Cristiano ;

Aurilia, Dario ;

Niarakis, Anna ;

La Ferla, Barbara ;

Salmona, Mario ;

Nicotra, Francesco ;

Gobbi, Marco ;

Antimisiaris, Sophia G. .

BIOMATERIALS, 2011, 32 (06) :1635-1645

[23] ULTRAVIOLET AND INFRARED SPECTRAL STUDIES OF POLYVINYLPYRROLIDONE [J].

OSTER, G ;

IMMERGUT, EH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1954, 76 (05) :1393-1396

[24] The nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas [J].

Senft, Christian ;

Polacin, Margareth ;

Priester, Maike ;

Seifert, Volker ;

Koegel, Donat ;

Weissenberger, Jakob .

BMC CANCER, 2010, 10

[25] Curcumin: The story so far [J].

Sharma, RA ;

Gescher, AJ ;

Steward, WP .

EUROPEAN JOURNAL OF CANCER, 2005, 41 (13) :1955-1968

[26]

Shipway AN, 2000, CHEMPHYSCHEM, V1, P18, DOI 10.1002/1439-7641(20000804)1:1<18::AID-CPHC18>3.0.CO

[27]

2-L

[28] Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo [J].

Song, Zhimei ;

Feng, Runliang ;

Sun, Min ;

Guo, Chenyu ;

Gao, Yan ;

Li, Lingbing ;

Zhai, Guangxi .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2011, 354 (01) :116-123

[29] Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents [J].

Souza, GR ;

Christianson, DR ;

Staquicini, FI ;

Ozawa, MG ;

Snyder, EY ;

Sidman, RL ;

Miller, JH ;

Arap, W ;

Pasqualini, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (05) :1215-1220

[30] Colorimetric Assay of Glutathione Based on the Spontaneous Disassembly of Aggregated Gold Nanocomposites Conjugated with Water-Soluble Polymer [J].

Uehara, Nobuo ;

Ookubo, Kouki ;

Shimizu, Tokuo .

LANGMUIR, 2010, 26 (09) :6818-6825

← 1 2 3 4 →