Conjugation of curcumin with PVP capped gold nanoparticles for improving bioavailability

被引：118

作者：

Gangwar, Rajesh K. ^{[1
]}

Dhumale, Vinayak A. ^{[1
]}

Kumari, Dimple ^{[2
]}

Nakate, Umesh T. ^{[1
]}

Gosavi, S. W. ^{[3
]}

Sharma, Rishi B. ^{[4
]}

Kale, S. N. ^{[1
]}

Datar, Suwarna ^{[1
]}

机构：

[1] Def Inst Adv Technol DU, Dept Appl Phys, Pune 411025, Maharashtra, India

[2] Def Inst Adv Technol DU, Dept Appl Chem, Pune 411025, Maharashtra, India

[3] Univ Pune, Dept Phys, Pune 411007, Maharashtra, India

[4] DRDO Bhawan, DOP, New Delhi 110105, India

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2012年 / 32卷 / 08期

关键词：

Curcumin; Gold nanoparticles; Bioavailability; BIOLOGICAL-ACTIVITIES; FORMULATION; DELIVERY; SIZE;

D O I：

10.1016/j.msec.2012.07.022

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Curcumin, a natural polyphenolic compound, has astounding therapeutic applications but lacks in bioavailability mainly due to its poor solubility in water. Polyvinyl pyrrolidone (PVP) which is a proven drug carrier has been used to facilitate the conjugation of curcumin with gold nanoparticles and to improve the solubility of curcumin in water. In this conjugate diaryl heptanoid chromophore group of curcumin which is a much needed group in biomedical applications remains intact as observed from FTIR and UV-vis spectroscopy analysis. The work shows good promise for such conjugates as therapeutic-cum-imaging materials in biomedical field. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：2659 / 2663

页数：5

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