Conjugation of curcumin with PVP capped gold nanoparticles for improving bioavailability

被引：118
作者：
Gangwar, Rajesh K. [1 ]
Dhumale, Vinayak A. [1 ]
Kumari, Dimple [2 ]
Nakate, Umesh T. [1 ]
Gosavi, S. W. [3 ]
Sharma, Rishi B. [4 ]
Kale, S. N. [1 ]
Datar, Suwarna [1 ]
机构：
[1] Def Inst Adv Technol DU, Dept Appl Phys, Pune 411025, Maharashtra, India
[2] Def Inst Adv Technol DU, Dept Appl Chem, Pune 411025, Maharashtra, India
[3] Univ Pune, Dept Phys, Pune 411007, Maharashtra, India
[4] DRDO Bhawan, DOP, New Delhi 110105, India
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2012年 / 32卷 / 08期
关键词：
Curcumin; Gold nanoparticles; Bioavailability; BIOLOGICAL-ACTIVITIES; FORMULATION; DELIVERY; SIZE;
D O I：
10.1016/j.msec.2012.07.022
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Curcumin, a natural polyphenolic compound, has astounding therapeutic applications but lacks in bioavailability mainly due to its poor solubility in water. Polyvinyl pyrrolidone (PVP) which is a proven drug carrier has been used to facilitate the conjugation of curcumin with gold nanoparticles and to improve the solubility of curcumin in water. In this conjugate diaryl heptanoid chromophore group of curcumin which is a much needed group in biomedical applications remains intact as observed from FTIR and UV-vis spectroscopy analysis. The work shows good promise for such conjugates as therapeutic-cum-imaging materials in biomedical field. (C) 2012 Elsevier B.V. All rights reserved.
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收藏
页码：2659 / 2663
页数：5
相关论文
共 34 条
[1]   Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature [J].
Anand, Preetha ;
Thomas, Sherin G. ;
Kunnumakkara, Ajaikumar B. ;
Sundaram, Chitra ;
Harikumar, Kuzhuvelil B. ;
Sung, Bokyung ;
Tharakan, Sheeja T. ;
Misra, Krishna ;
Priyadarsini, Indira K. ;
Rajasekharan, Kallikat N. ;
Aggarwal, Bharat B. .
BIOCHEMICAL PHARMACOLOGY, 2008, 76 (11) :1590-1611
[2]   Bioavailability of curcumin: Problems and promises [J].
Anand, Preetha ;
Kunnumakkara, Ajaikumar B. ;
Newman, Robert A. ;
Aggarwal, Bharat B. .
MOLECULAR PHARMACEUTICS, 2007, 4 (06) :807-818
[3]   RETRACTED: Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo (Retracted article. See vol. 102, pg. 143, 2016) [J].
Anand, Preetha ;
Nair, Hareesh B. ;
Sung, Bokyung ;
Kunnumakkara, Ajaikumar B. ;
Yadav, Vivek R. ;
Tekmal, Rajeshwar R. ;
Aggarwal, Bharat B. .
BIOCHEMICAL PHARMACOLOGY, 2010, 79 (03) :330-338
[4]  
[Anonymous], ADV NAT SCI NANOSCI
[5]   Curcumin Nanoparticles: Preparation, Characterization, and Antimicrobial Study [J].
Bhawana ;
Basniwal, Rupesh Kumar ;
Buttar, Harpreet Singh ;
Jain, V. K. ;
Jain, Nidhi .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2011, 59 (05) :2056-2061
[6]   Polymeric nanoparticle-encapsulated curcumin (nanocurcumin"): A novel strategy for human cancer therapy" [J].
Bisht S. ;
Feldmann G. ;
Soni S. ;
Ravi R. ;
Karikar C. ;
Maitra A. ;
Maitra A. .
Journal of Nanobiotechnology, 5 (1)
[7]  
Chattopadhyay I, 2004, CURR SCI INDIA, V87, P44
[8]   Gold nanoparticles: Assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology [J].
Daniel, MC ;
Astruc, D .
CHEMICAL REVIEWS, 2004, 104 (01) :293-346
[9]   Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain [J].
Daniel, S ;
Limson, JL ;
Dairam, A ;
Watkins, GM ;
Daya, S .
JOURNAL OF INORGANIC BIOCHEMISTRY, 2004, 98 (02) :266-275
[10]   Curcumin-loaded γ-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma [J].
Dhule, Santosh S. ;
Penfornis, Patrice ;
Frazier, Trivia ;
Walker, Ryan ;
Feldman, Joshua ;
Tan, Grace ;
He, Jibao ;
Alb, Alina ;
John, Vijay ;
Pochampally, Radhika .
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2012, 8 (04) :440-451
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