Synthesis of Novel 4-[1-(3-Chlorophenyl)-3-(pyren-1-yl)-1H-pyrazol-4-yl]-6-(substituted phenyl)-1,2-dihydro-2-oxo(imino)pyridine-3-carbonitriles

被引:1
|
作者
Khalifa, N. M. [1 ,2 ]
Al-Omar, M. A. [1 ]
Ali, O. M. [3 ]
机构
[1] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, Drug Explorat & Dev Chair, Riyadh 11451, Saudi Arabia
[2] Natl Res Ctr, Pharmaceut & Drug Ind Div, Therapeut Chem Dept, Cairo 12622, Egypt
[3] Taif Univ, Fac Med & Appl Sci, Dept Chem, At Taif, Saudi Arabia
关键词
1,3,4-trisubstituted pyrazoles; 2-oxo(imino)pyridine derivatives; synthesis; PYRENE MOIETY; DERIVATIVES;
D O I
10.1134/S1070363217120349
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A novel compounds of 4,6-diaryl-2-oxo(imino)-1,2-dihydro-pyridine-3-carbonitriles has been synthesized by reaction of 1-(3-chlorophenyl)-3-(pyren-1-yl)-1H-pyrazole-4-carbaldehyde with different 1-(substituted phenyl)ethanones and ethyl cyanoacetate or malononitrile in presence of ammonium acetate. Structure of the newly synthesized compounds was elucidated from chemical and spectroscopic data.
引用
收藏
页码:2933 / 2936
页数:4
相关论文
共 50 条
  • [1] Synthesis of Novel 4-[1-(3-Chlorophenyl)-3-(pyren-1-yl)-1H-pyrazol-4-yl]-6-(substituted phenyl)-1,2-dihydro-2-oxo(imino)pyridine-3-carbonitriles
    N. M. Khalifa
    M. A. Al-Omar
    O. M. Ali
    Russian Journal of General Chemistry, 2017, 87 : 2933 - 2936
  • [2] Synthesis of Novel 4-[1-(3-Chlorophenyl)-3-(pyren-1-yl)-1H-pyrazol-4-yl]-2-alkyloxy-6-substituted pyridine-3-carbonitriles
    Khalifa, N. M.
    Al-Omar, M. A.
    Taha, M. M.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2017, 87 (12) : 2966 - 2969
  • [3] Synthesis of Novel 4-[1-(3-Chlorophenyl)-3-(pyren-1-yl)-1H-pyrazol-4-yl]-2-alkyloxy-6-substituted pyridine-3-carbonitriles
    N. M. Khalifa
    M. A. Al-Omar
    M. M. Taha
    Russian Journal of General Chemistry, 2017, 87 : 2966 - 2969
  • [4] Synthesis and characterization of novel chalcones linked 3-[1-(3-chlorophenyl)-3-(pyren-1-yl)]-1H-pyrazole moiety
    Khalifa, N. M.
    Al-Omar, M. A.
    Ali, O. M.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2017, 87 (11) : 2699 - 2702
  • [5] Synthesis and characterization of novel chalcones linked 3-[1-(3-chlorophenyl)-3-(pyren-1-yl)]-1H-pyrazole moiety
    N. M. Khalifa
    M. A. Al-Omar
    O. M. Ali
    Russian Journal of General Chemistry, 2017, 87 : 2699 - 2702
  • [6] Synthesis and some reactions of novel (4Z)-4-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]methylene}-2-hydrazinyl-1-phenyl-1H-imidazol-5(4H)-ones
    N. M. Khalifa
    M. A. Al-Omar
    E. S. Nossier
    Russian Journal of General Chemistry, 2017, 87 : 1621 - 1626
  • [7] Synthesis and some reactions of novel (4Z)-4-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]methylene}-2-hydrazinyl-1-phenyl-1H-imidazol-5(4H)-ones
    Khalifa, N. M.
    Al-Omar, M. A.
    Nossier, E. S.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2017, 87 (07) : 1621 - 1626
  • [8] Synthesis and antimicrobial screening of some 3-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] and 4-methyl-3-phenyl-6-[4-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-6-aryl-pyridin-2-yl] coumarins
    Brahmbhatt, D. I.
    Kaneria, Ankit R.
    Patel, Anil K.
    Patel, Niraj H.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2010, 49 (07): : 971 - 977
  • [9] 1-{5-[4-(Hexyloxy)phenyl]-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl}ethanone
    Abbas, Asghar
    Hussain, Safdar
    Hafeez, Noureen
    Lo, Kong Mun
    Hasan, Aurangzeb
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2010, 66 : O2505 - U1872
  • [10] Synthesis and biological activity of 4-[5(4-substituted phenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
    Havaldar, FH
    Khatri, NK
    ASIAN JOURNAL OF CHEMISTRY, 2004, 16 (3-4) : 1573 - 1576