Transformation to small-cell lung cancer following treatment with EGFR tyrosine kinase inhibitors in a patient with lung adenocarcinoma

被引：90

作者：

Watanabe, Satoshi ^{[1
]}

Sone, Takashi ^{[1
]}

Matsui, Tomoharu ^{[1
]}

Yamamura, Kenta ^{[1
]}

Tani, Mayuko ^{[1
]}

Okazaki, Akihito ^{[1
]}

Kurokawa, Koji ^{[1
]}

Tambo, Yuichi ^{[1
]}

Takato, Hazuki ^{[1
]}

Ohkura, Noriyuki ^{[1
]}

Waseda, Yuko ^{[1
]}

Katayama, Nobuyuki ^{[1
]}

Kasahara, Kazuo ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Med, Dept Resp Med, Kanazawa, Ishikawa 9208641, Japan

来源：

LUNG CANCER | 2013年 / 82卷 / 02期

关键词：

Small cell lung cancer; Transformation; EGFR tyrosine kinase inhibitors; Adenocarcinoma; Resistance; NSE; ProGRP; GEFITINIB RESISTANCE; ACQUIRED-RESISTANCE; MUTATIONS;

D O I：

10.1016/j.lungcan.2013.06.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the case of a 52-year-old woman with lung adenocarcinoma treated with EGFR tyrosine kinase inhibitor (TKI) therapy. After disease progression, histological examination of a secondary biopsy specimen revealed small-cell lung cancer (SCLC) that was sensitive to standard SCLC treatment. Tumor markers, including ProGRP and NSE, were elevated. Transformation to SCLC is a mechanism for acquired resistance to EGFR-TKI therapy. Secondary biopsy is important for evaluation of genetic and histological changes and selection of appropriate treatment. Furthermore, ProGRP and NSE may be useful for early detection of SCLC transformation in cases resistant to EGFR-TKI therapy. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：370 / 372

页数：3

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