Genetics, prevalence, screening and confirmation of primary aldosteronism: a position statement and consensus of the Working Group on Endocrine Hypertension of The European Society of Hypertension*

被引：217

作者：

Mulatero, Paolo ^{[1
,2
]}

Monticone, Silvia ^{[1
,2
]}

Deinum, Jaap ^{[3
,4
]}

Amar, Laurence ^{[5
]}

Prejbisz, Aleksander ^{[6
]}

Zennaro, Maria-Christina ^{[7
,8
]}

Beuschlein, Felix ^{[9
,10
]}

Rossi, Gian Paolo ^{[11
,12
]}

Nishikawa, Tetsuo ^{[13
]}

Morganti, Alberto ^{[14
]}

Seccia, Teresa Maria ^{[11
,12
]}

Lin, Yen-Hung ^{[15
,16
]}

Fallo, Francesco ^{[17
]}

Widimsky, Jiri ^{[18
,19
]}

机构：

[1] Univ Torino, Dept Med Sci, Div Internal Med, Via Genova 3, I-10126 Turin, Italy

[2] Univ Torino, Dept Med Sci, Hypertens Unit, Via Genova 3, I-10126 Turin, Italy

[3] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[4] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Med 3, Dresden, Germany

[5] Univ Paris, Hop Europeen Georges Pompidou, AP HP, PARCC,Hypertens Unit,INSERM, Paris, France

[6] Natl Inst Cardiol, Dept Hypertens, Warsaw, Poland

[7] Univ Paris, INSERM, PARCC, Paris, France

[8] Hop Europeen Georges Pompidou, AP HP, Serv Genet, Paris, France

[9] Univ Spital Zurich, Klin Endokrinol Diabetol & Klin Ernahrung, Zurich, Switzerland

[10] Klinikum Univ Munchen, Med Klin & Poliklin 4, Munich, Germany

[11] Univ Padua, Hypertens Unit, Padua, Italy

[12] Univ Padua, Dept Med DIMED, Specialized Ctr Blood Pressure Disorders, Padua, Italy

[13] Yokohama Rosai Hosp, Endocrinol & Diabet Ctr, Yokohama, Kanagawa, Japan

[14] Univ Milan, Ctr Fisiol Clin & Ipertens, Osped Policlin, Milan, Italy

[15] Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiol, Taipei, Taiwan

[16] Natl Taiwan Univ, Coll Med, Taipei, Taiwan

[17] Univ Padua, Dept Med DIMED, Padua, Italy

[18] Charles Univ Prague, Gen Univ Hosp, Ctr Hypertens, Dept Med 3, Prague, Czech Republic

[19] Charles Univ Prague, Fac Med 1, Prague, Czech Republic

来源：

JOURNAL OF HYPERTENSION | 2020年 / 38卷 / 10期

关键词：

aldosterone; primary aldosteronism; rennin; saline-loading test; PLASMA-RENIN ACTIVITY; FAMILIAL HYPERALDOSTERONISM; ANTIHYPERTENSIVE MEDICATION; ATRIAL-FIBRILLATION; CHANNEL MUTATIONS; DIAGNOSIS; RATIO; ADRENALECTOMY; VALIDATION; MANAGEMENT;

D O I：

10.1097/HJH.0000000000002510

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Autonomous aldosterone overproduction represents the underlying condition of 5-10% of patients with arterial hypertension and carries a significant burden of mortality and morbidity. The diagnostic algorithm for primary aldosteronism is sequentially based on hormonal tests (screening and confirmation tests), followed by lateralization studies (adrenal CT scanning and adrenal venous sampling) to distinguish between unilateral and bilateral disease. Despite the recommendations of the Endocrine Society guideline, primary aldosteronism is largely underdiagnosed and undertreated with high between-centre heterogeneity. Experts from the European Society of Hypertension have critically reviewed the available literature and prepared a consensus document constituting two articles to summarize current knowledge on the epidemiology, diagnosis, treatment, and complications of primary aldosteronism.

引用

页码：1919 / 1928

页数：10

共 81 条

[21] Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis [J].