Long non-coding RNA implicated in the invasion and metastasis of head and neck cancer: possible function and mechanisms

被引:70
作者
Luo, Xiaobo [1 ,2 ,3 ,4 ]
Qiu, Yan [5 ,6 ]
Jiang, Yuchen [1 ,2 ,3 ]
Chen, Fangman [1 ,2 ,3 ]
Jiang, Lu [1 ,2 ,3 ]
Zhou, Yu [1 ,2 ,3 ]
Dan, Hongxia [1 ,2 ,3 ]
Zeng, Xin [1 ,2 ,3 ]
Lei, Yu L. [4 ,7 ,8 ]
Chen, Qianming [1 ,2 ,3 ]
机构
[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, 14,Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, 14,Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, West China Hosp Stomatol, Dept Oral Med, 14,Sec 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China
[4] Univ Michigan, Comprehens Canc Ctr, Sch Dent, Dept Periodont & Oral Med, 1600 Huron Pkwy 2355, Ann Arbor, MI 48109 USA
[5] Sichuan Univ, West China Hosp, Clin Res Ctr Breast, Lab Pathol, Chengdu 610041, Sichuan, Peoples R China
[6] Sichuan Univ, West China Hosp, Dept Pathol, Chengdu 610041, Sichuan, Peoples R China
[7] Univ Michigan, Comprehens Canc Ctr, Ann Arbor, MI 48109 USA
[8] Univ Michigan Hlth Syst, Dept Otolaryngol Head & Neck Surg, 1600 Huron Pkwy 2355, Ann Arbor, MI 48109 USA
基金
中国国家自然科学基金;
关键词
Long noncoding RNA; Invasion; Metastasis; Head and neck cancer; Mechanism; SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; NF-KAPPA-B; HUMAN NASOPHARYNGEAL CARCINOMA; POOR-PROGNOSIS; UP-REGULATION; COLON-CANCER; PROMOTES PROLIFERATION; TUMOR-SUPPRESSOR; MALAT1; PROMOTES;
D O I
10.1186/s12943-018-0763-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Head and neck cancer (HNC) ranks as the 6th most common malignancy across the world. Metastasis is a hallmark of cancer, primarily contributing to the relapse and poor prognosis of HNC. Recently, long noncoding RNAs (lncRNAs), previously considered as non-functional, are increasingly appreciated by scholars to play crucial roles in mediating HNC metastasis. LncRNAs, which are located in the nucleus and cytoplasm, mainly exert their function via epigenetic modification, transcriptional control and translational regulation. As several lncRNAs are presently demonstrated to participate in HNC metastasis, we make a summary of the functions and mechanisms regarding these lncRNAs. As shown in the literature, most lncRNAs appear to promote the metastasis of HNC. Hence, we primarily discuss the lncRNAs involved in enhancing metastasis. Additionally, more studies are needed to understand those lncRNAs without clear mechanisms. Furthermore, we introduced the upstream regulator for the aberrant expression of lncRNAs in HNC. Finally, we concisely addressed future research prospects of lncRNAs, particularly the interplay between lncRNAs and tumor immunity as well as lncRNA-targeted therapeutic techniques, and we introduced clustered regularly interspaced short palindromic repeats (CRISPR)-Display as a possibly transformative tool to study lncRNAs. Although lncRNA research is still in the initial stage, it holds great promise to be applied as a prognosticator of HNC and a therapeutic target to inhibit HNC metastasis, which could significantly enhance the outcome of HNC patients.
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页数:16
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