Heparin-binding epidermal growth factor-like growth factor protects rat intestine after portal triad clamping

被引：3
作者：
Liao, Xinxin [1 ]
Chen, Liyan [1 ]
Fu, Wenguang [1 ]
Zhou, Jie [1 ]
机构：
[1] Southern Med Univ, Nanfang Hosp, Dept Hepatobiliary Surg, Guangzhou 510515, Guangdong, Peoples R China
来源：
GROWTH FACTORS | 2013年 / 31卷 / 02期
关键词：
Portal triad clamping; intestine; protect; reperfusion injury; heparin-binding EGF-like growth factor; ISCHEMIA/REPERFUSION INJURY; ISCHEMIA-REPERFUSION; FACTOR DECREASES; BACTERIAL TRANSLOCATION; HEPATIC RESECTION; PRINGLE MANEUVER; ORGAN FAILURE; IN-VITRO; EGF; CONGESTION;
D O I：
10.3109/08977194.2013.784757
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a potent mitogen and chemotactic factor. HB-EGF attenuates intestinal ischemia/reperfusion injury caused by superior mesenteric artery occlusion. We examined whether HB-EGF offers protection against intestinal congestion/reperfusion (C/R) injury, which is caused by portal triad clamping. Male Sprague-Dawley rats were randomly divided into three equally sized groups: I, sham-operated; II, portal triad clamping (Pringle maneuver); III, II + intraluminal administration of HB-EGF. Compared with sham-operated rats, all rats in group II exhibited significant increases in intestinal histologic injury, pro-inflammatory cytokine expression, myeloperoxidase activity, malonaldehyde levels, and apoptosis indices. Intraluminal administration of HB-EGF in group III significantly reduced these indicators when compared with group II. Clamping of the portal triad followed by reperfusion causes intestinal C/R injury and intraluminal administration of HB-EGF reduces the severity of intestinal C/R injury in rats.
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页码：74 / 80
页数：7
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