Transforming growth factor-β in tumour development

被引：27

作者：

Trelford, Charles B. ^{[1
]}

Dagnino, Lina ^{[1
,2
,3
]}

Di Guglielmo, Gianni M. ^{[1
]}

机构：

[1] Western Univ, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON, Canada

[2] Childrens Hlth Res Inst, Dept Oncol, London, ON, Canada

[3] Lawson Hlth Res Inst, London, ON, Canada

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2022年 / 9卷

关键词：

transforming growth factor-b (TGFb); Smad; receptor trafficking; epithelial-mesenchymal transition (EMT); autophagy; protein; 62; sequestosome 1 (p62; SQSTM1); EPITHELIAL-MESENCHYMAL TRANSITION; FYVE DOMAIN PROTEIN; TGF-BETA; ENDOTHELIAL-CELLS; LATENT TGF-BETA-1; CRYSTAL-STRUCTURE; CANCER-CELLS; TRANSCRIPTION FACTORS; MEDIATED ACTIVATION; ACTIN CYTOSKELETON;

D O I：

10.3389/fmolb.2022.991612

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transforming growth factor-beta (TGF beta) is a ubiquitous cytokine essential for embryonic development and postnatal tissue homeostasis. TGF beta signalling regulates several biological processes including cell growth, proliferation, apoptosis, immune function, and tissue repair following injury. Aberrant TGF beta signalling has been implicated in tumour progression and metastasis. Tumour cells, in conjunction with their microenvironment, may augment tumourigenesis using TGF beta to induce epithelial-mesenchymal transition, angiogenesis, lymphangiogenesis, immune suppression, and autophagy. Therapies that target TGF beta synthesis, TGF beta-TGF beta receptor complexes or TGF beta receptor kinase activity have proven successful in tissue culture and in animal models, yet, due to limited understanding of TGF beta biology, the outcomes of clinical trials are poor. Here, we review TGF beta signalling pathways, the biology of TGF beta during tumourigenesis, and how protein quality control pathways contribute to the tumour-promoting outcomes of TGF beta signalling.

引用

页数：29

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