Reduced limbic metabolism and fronto-cortical volume in rats vulnerable to alcohol addiction

被引:32
作者
Gozzi, Alessandro [1 ,2 ]
Agosta, Federica [3 ]
Massi, Maurizio [4 ]
Ciccocioppo, Roberto [4 ]
Bifone, Angelo [1 ,2 ]
机构
[1] Ist Italiano Tecnol, Ctr Nanotechnol Innovat, Pisa, Italy
[2] UniTn, Ctr Neurosci & Cognit Syst, Rovereto, Italy
[3] GlaxoSmithKline Med Res Mentre, Verona, Italy
[4] Univ Camerino, I-62032 Camerino, Italy
关键词
Alcohol; VBM; fMRI; Grey matter; Addiction; Metabolism; POSITRON-EMISSION-TOMOGRAPHY; TERM ABSTINENT ALCOHOLICS; SUBSTANCE USE DISORDERS; CEREBRAL BLOOD-VOLUME; BRAIN METABOLISM; FAMILY-HISTORY; HIGH-RISK; PREFRONTAL CORTEX; WHITE-MATTER; ANXIETY;
D O I
10.1016/j.neuroimage.2012.12.015
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Alcohol abuse is associated with long-term reductions in fronto-cortical volume and limbic metabolism. However, an unanswered question in alcohol research is whether these alterations are the sole consequence of chronic alcohol use, or contain heritable contributions reflecting biological propensity toward ethanol addiction. Animal models of genetic predisposition to alcohol dependence can be used to investigate the role of inborn brain abnormalities in the aetiology of alcoholism. Here we used magnetic resonance imaging (MRI) in the Marchigian-Sardinian (msP) alcohol-preferring rats to assess the presence of inherited structural or functional brain alterations. Alcohol-naive msP (N = 22) and control rats (N = 26) were subjected to basal cerebral blood volume (bCBV) mapping followed by voxel-based morphometry (VBM) of grey matter and tract-based spatial statistics mapping of white matter fractional anisotropy. msP rats exhibited significantly reduced bCBV, an established marker of resting brain function, in focal cortico-limbic and thalamic areas, together with reduced grey matter volume in the thalamus, ventral tegmental area, insular and cingulate cortex. No statistically significant differences in fractional anisotropy were observed between groups. These findings highlight the presence of inborn grey matter and metabolic abnormalities in alcohol-naive msP rats, the localization and sign of which are remarkably similar to those mapped in abstinent alcoholics and subjects at high risk for alcohol dependence. Collectively, these results point for a significant role of heritable neurofunctional brain alterations in biological propensity toward ethanol addiction, and support the translational use of advanced imaging methods to describe the circuital determinants of vulnerability to drug addiction. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:112 / 119
页数:8
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