Type 1 and type 2 cytokine profile in AIDS-Kaposi's sarcoma patients after highly active antiretroviral therapy

被引：0

作者：

Sirianni, MC ^{[1
]}

Vincenzi, L ^{[1
]}

Topino, S ^{[1
]}

Mezzaroma, I ^{[1
]}

Pinter, E ^{[1
]}

Barbone, B ^{[1
]}

Monini, P ^{[1
]}

Ensoli, B ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Clin Med, Rome, Italy

来源：

FOURTH EUROPEAN CONFERENCE ON EXPERIMENTAL AIDS RESEARCH | 1999年

关键词：

D O I：

暂无

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Recent studies show that AIDS-Kaposi's sarcoma (AIDS-KS) can regress upon highly active antiretroviral therapy (HAART). KS is characterized by the production of cellular gamma Interferon (gamma IFN) mediating KS lesions development and angiogenesis. The aim of our study was to assess the production of gamma IFN and Interleukin (IL)-4 in peripheral blood lymphocytes (PBMC) derived from AIDS-KS patients before and after HAART. To this purpose, PBMC were cultured in the presence or absence of rIL-2 enriched T-cell conditioned media (TCM) that contain the same type 1 cytokines increased in KS patients. TCM has been used to culture lymphocytes infiltrating KS tissue (TIL). The data show that PBMC from patients in HAART release gamma IFN at increased levels in the presence of TCM but gamma IFN production declines after HAART in cultures maintained in the absence of TCM.

引用

页码：167 / 171

页数：5

共 14 条

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