New insights into the roles of ncRNA in the STAT3 pathway

被引：0

作者：

Zhang, Junxia ^{[1
,2
]}

Zhang, Anlin ^{[1
,2
]}

Wang, Yingyi ^{[3
]}

Liu, Ning ^{[3
]}

You, Yongping ^{[3
]}

Kang, Chunsheng ^{[1
,2
]}

Pu, Peiyu ^{[1
,2
]}

机构：

[1] Tianjin Med Univ, Gen Hosp, Dept Neurosurg, Lab Neurooncol, Tianjin 300052, Peoples R China

[2] Tianjin Key Lab Nerve Injury Variat & Regenerat, Tianjin 300052, Peoples R China

[3] Nanjing Med Univ, Dept Neurosurg, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China

来源：

FUTURE ONCOLOGY | 2012年 / 8卷 / 06期

关键词：

cancer; IncRNA; miRNA; STAT3; BREAST-CANCER CELLS; LONG NONCODING RNA; GROWTH-SUPPRESSIVE ACTIVITY; SIGNAL TRANSDUCER; TRANSCRIPTION; TUMOR SUPPRESSORS; EXPRESSION; MICRORNAS; SURVIVAL; GENE;

D O I：

10.2217/FON.12.52

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

STAT3 signaling has been linked to the development of various cancers and is widely recognized as a critical molecular target for cancer therapy. ncRNAs, especially miRNAs and IncRNAs, are acting as promising biomarkers and therapy targets implicated in tumor pathogenesis. This review focuses on the most up-to-date knowledge of miRNAs and IncRNAs, and their involvement with STAT3 signaling. The important miRNAs involved in the STAT3 pathway are summarized in a complex interaction network. The IncRNAs' potential for targeting STAT3 at post-transcriptional level was predicted based upon IncRNA-mRNA interaction. The current and potential STAT3-targeted therapeutics are also discussed.

引用

页码：723 / 730

页数：8

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