Human cancer germline antigen-specific cytotoxic T cell-what can we learn from patient

被引：13

作者：

Abd Hamid, Megat ^{[1
]}

Peng, Yanchun ^{[1
,2
]}

Dong, Tao ^{[1
,2
]}

机构：

[1] Univ Oxford, Chinese Acad Med Sci Oxford Inst COI, Nufield Dept Med, Oxford, England

[2] Univ Oxford, MRC Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford, England

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2020年 / 17卷 / 07期

基金：

英国医学研究理事会;

关键词：

cytotoxic T cell; immune check point receptor; immune therapy; T cell receptor; cancer antigen; TUMOR-INFILTRATING LYMPHOCYTES; LYTIC GRANULE POLARIZATION; HLA-E; METASTATIC MELANOMA; ADOPTIVE TRANSFER; IFN-GAMMA; INHIBITORY RECEPTOR; CLINICAL ACTIVITY; DOWN-REGULATION; CO-STIMULATION;

D O I：

10.1038/s41423-020-0468-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this review, we will highlight the importance of cancer germline antigen-specific cytotoxic CD8(+) T lymphocytes (CTL) and the factors affecting antitumor CTL responses. In light of cancer immunotherapy, we will emphasis the need to further understand the features, characteristics, and actions of modulatory receptors of human cancer germline-specific CTLs, in order to determine the optimal conditions for antitumor CTL responses.

引用

页码：684 / 692

页数：9

共 144 条

[1] Defective Interferon Gamma Production by Tumor-Specific CD8+ T Cells Is Associated With 5′Methylcytosine-Guanine Hypermethylation of Interferon Gamma Promoter [J].

Abd Hamid, Megat ;

Yao, Xuan ;

Waugh, Craig ;

Rosendo-Machado, Samara ;

Li, Chris ;

Rostron, Timothy ;

Frankland, John ;

Peng, Yanchun ;

Dong, Tao .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[2] Self-Maintaining CD103+ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses [J].

Abd Hamid, Megat ;

Colin-York, Huw ;

Khalid-Alham, Nasullah ;

Browne, Molly ;

Cerundolo, Lucia ;

Chen, Ji-Li ;

Yao, Xuan ;

Rosendo-Machado, Samara ;

Waugh, Craig ;

Maldonado-Perez, David ;

Bowes, Emma ;

Verrill, Clare ;

Cerundolo, Vincenzo ;

Conlon, Christopher P. ;

Fritzsche, Marco ;

Peng, Yanchun ;

Dong, Tao .

CANCER IMMUNOLOGY RESEARCH, 2020, 8 (02) :203-216

[3] Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8+ Tumor-Infiltrating T Lymphocyte Responses [J].

Abd Hamid, Megat ;

Wang, Ruo-Zheng ;

Yao, Xuan ;

Fan, Peiwen ;

Li, Xi ;

Chang, Xue-Mei ;

Feng, Yaning ;

Jones, Stephanie ;

Maldonado-Perez, David ;

Waugh, Craig ;

Verrill, Clare ;

Simmons, Alison ;

Cerundolo, Vincenzo ;

McMichael, Andrew ;

Conlon, Christopher ;

Wang, Xiyan ;

Peng, Yanchun ;

Dong, Tao .

CANCER IMMUNOLOGY RESEARCH, 2019, 7 (08) :1293-1306

[4] Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes [J].

Agata, Y ;

Kawasaki, A ;

Nishimura, H ;

Ishida, Y ;

Tsubata, T ;

Yagita, H ;

Honjo, T .

INTERNATIONAL IMMUNOLOGY, 1996, 8 (05) :765-772

[5] Different affinity windows for virus and cancer-specific T-cell receptors: Implications for therapeutic strategies [J].

Aleksic, Milos ;

Liddy, Nathaniel ;

Molloy, Peter E. ;

Pumphrey, Nick ;

Vuidepot, Annelise ;

Chang, Kyong-Mi ;

Jakobsen, Bent K. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2012, 42 (12) :3174-3179

[6] Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells [J].

Andre, Pascale ;

Denis, Caroline ;

Soulas, Caroline ;

Bourbon-Caillet, Clarisse ;

Lopez, Julie ;

Arnoux, Thomas ;

Blery, Mathieu ;

Bonnafous, Cecile ;

Gauthier, Laurent ;

Morel, Ariane ;

Rossi, Benjamin ;

Remark, Romain ;

Breso, Violette ;

Bonnet, Elodie ;

Habif, Guillaume ;

Guia, Sophie ;

Lalanne, Ana Ines ;

Hoffmann, Caroline ;

Lantz, Olivier ;

Fayette, Jerome ;

Boyer-Chammard, Agnes ;

Zerbib, Robert ;

Dodion, Pierre ;

Ghadially, Hormas ;

Jure-Kunkel, Maria ;

Morel, Yannis ;

Herbst, Ronald ;

Narni-Mancinelli, Emilie ;

Cohen, Roger B. ;

Vivier, Eric .

CELL, 2018, 175 (07) :1731-+

[7]

[Anonymous], J HEMATOL ONCOL

[8] Clinical Experiences With Anti-CD137 and Anti-PD1 Therapeutic Antibodies [J].

Ascierto, Paolo A. ;

Simeone, Ester ;

Sznol, Mario ;

Fu, Yang-Xin ;

Melero, Ignacio .

SEMINARS IN ONCOLOGY, 2010, 37 (05) :508-516

[9] Tumor-Infiltrating Lymphocyte Grade Is an Independent Predictor of Sentinel Lymph Node Status and Survival in Patients With Cutaneous Melanoma [J].

Azimi, Farhad ;

Scolyer, Richard A. ;

Rumcheva, Pavlina ;

Moncrieff, Marc ;

Murali, Rajmohan ;

McCarthy, Stanley W. ;

Saw, Robyn P. ;

Thompson, John F. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (21) :2678-2683

[10] Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma: Intent-to-Treat Analysis and Efficacy after Failure to Prior Immunotherapies [J].

Besser, Michal J. ;

Shapira-Frommer, Ronnie ;

Itzhaki, Orit ;

Treves, Avraham J. ;

Zippel, Douglas B. ;

Levy, Daphna ;

Kubi, Adva ;

Shoshani, Noa ;

Zikich, Dragoslav ;

Ohayon, Yaara ;

Ohayon, Daniel ;

Shalmon, Bruria ;

Markel, Gal ;

Yerushalmi, Ronit ;

Apter, Sara ;

Ben-Nun, Alon ;

Ben-Ami, Eytan ;

Shimoni, Avichai ;

Nagler, Arnon ;

Schachter, Jacob .

CLINICAL CANCER RESEARCH, 2013, 19 (17) :4792-4800

← 1 2 3 4 5 6 7 8 9 10 →