The mechanism and efficacy of GLP-1 receptor agonists in the treatment of Alzheimer's disease

被引：58

作者：

Du, Haiyang ^{[1
]}

Meng, Xiaoyu ^{[2
,3
]}

Yao, Yu ^{[1
]}

Xu, Jun ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Orthoped, Div Orthoped, Harbin, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Internal Med,Div Endocrinol, Wuhan, Peoples R China

[3] Branch Natl Clin Res Ctr Metab Dis, Wuhan, Hubei, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷

关键词：

Alzheimer's disease; GLP-1R agonists; cognitive function; amyloid beta; tau phosphorylation; GLUCAGON-LIKE PEPTIDE-1; AMYLOID-BETA PROTEIN; MODULATING TAU HYPERPHOSPHORYLATION; INTRACELLULAR CALCIUM HOMEOSTASIS; PROGENITOR-CELL PROLIFERATION; BRAIN INSULIN-RESISTANCE; LONG-TERM POTENTIATION; MOUSE MODEL; MEMORY IMPAIRMENT; SYNAPTIC PLASTICITY;

D O I：

10.3389/fendo.2022.1033479

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease (AD) and both have the same pathogenesis (e.g., insulin resistance), drugs used to treat T2DM have been gradually found to reduce the progression of AD in AD models. Of these drugs, glucagon-like peptide 1 receptor (GLP-1R) agonists are more effective and have fewer side effects. GLP-1R agonists have reducing neuroinflammation and oxidative stress, neurotrophic effects, decreasing A beta deposition and tau hyperphosphorylation in AD models, which may be a potential drug for the treatment of AD. However, this needs to be verified by further clinical trials. This study aims to summarize the current information on the mechanisms and effects of GLP-1R agonists in AD.

引用

页数：18

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