Stereoselective dioxygenase-catalysed benzylic hydroxylation at prochiral methylene groups in the chemoenzymatic synthesis of enantiopure vicinal aminoindanols.

被引：43

作者：

Boyd, DR

Sharma, ND

Bowers, NI

Goodrich, PA

Groocock, MR

Blacker, AJ

Clarke, DA

Howard, T

Dalton, H

机构：

[1] ZENECA PTD,HUDDERSFIELD HD2 1FF,YORKS,ENGLAND

[2] UNIV WARWICK,DEPT BIOL SCI,COVENTRY CV4 7AL,W MIDLANDS,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 06期

关键词：

D O I：

10.1016/0957-4166(96)00180-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantiopure benzylic alcohols containing two stereogenic centres in a cis-relationship result from stereoselective monohydroxylation of achiral 2-substituted indans in cultures of Pseudomonas putida UV4 and are used in the chemoenzymatic synthesis of both cis- and trans-aminoindanol enantiomers. (C) 1996 Elsevier Science Ltd

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页码：1559 / 1562

页数：4

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