Adipose-derived mesenchymal stem cells ameliorate lung epithelial injury through mitigating of oxidative stress in mustard lung

被引：8
|
作者：
Marzouni, Eisa Tahmasbpour [1 ]
Dorcheh, Setareh Panahi [2 ]
Nejad-Moghaddam, Amir [3 ,4 ]
Ghanei, Mostafa [5 ]
Goodarzi, Hassan [5 ]
Hosseini, Seyedeh Esmat [6 ,7 ]
Madani, Hoda [7 ]
机构：
[1] Pasteur Inst Iran, Lab Regenerat Med & Biomed Innovat, Tehran, Iran
[2] Islamic Azad Univ, Sci & Res Branch, Dept Cellular & Mol Biol, Tehran, Iran
[3] Baqiyatallah Univ Med Sci, Marine Med Res Ctr, Tehran, Iran
[4] Imam Khamenei Univ, Fac Sci, Dept Basic Sci, Zibakenar, Rasht, Iran
[5] Baqiyatallah Univ Med Sci, Syst Biol & Poisonings Inst, Chem Injuries Res Ctr, Tehran, Iran
[6] Shahid Beheshti Univ Med Sci, Sch Nursing & Midwifery, Student Res Comm, Tehran, Iran
[7] ACECR, Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Regenerat Biomed, Tehran, Iran
来源：
REGENERATIVE MEDICINE | 2020年 / 15卷 / 07期
基金：
美国国家科学基金会;
关键词：
airway remodeling; antioxidants; lung regeneration; mesenchymal stem cells; mustard lung; oxidative stress; SULFUR MUSTARD; ANTIOXIDANT DEFENSE; LIPID-PEROXIDATION; EXPOSURE; OVEREXPRESSION; COMPLICATIONS; CONSEQUENCES; INFLAMMATION; GLUTATHIONE; EXPRESSION;
D O I：
10.2217/rme-2020-0051
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Aim:We investigated potential efficacy of autologous adipose-derived mesenchymal stem cell (MSC) on oxidative stress (OS) and airway remodeling in patients with chronic mustard lung.Patients & methods:Ten patients received 100 x 10(6)cells every 20 days for 4 injections over a 2-month period.Results:A gradual improvement was observed for 6 min walk test scores, pulmonary function tests and respiratory quality after MSCs therapy. A significant decrease was found for the mean levels of Mucin-1 protein (KL-6; p = 0.022) and Clara cell protein 16 (CC16; p = 0.005). Antioxidants had a tendency to be higher after each injection.Conclusion:Our findings revealed that MSCs therapy can be safely used for improvement of lung injury and regeneration in these patients without adverse effects.
引用
收藏
页码：1861 / 1876
页数：16
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