Osteocyte control of osteoclastogenesis

被引：177

作者：

O'Brien, Charles A. ^{[1
,2
]}

Nakashima, Tomoki ^{[3
,4
]}

Takayanagi, Hiroshi ^{[3
,4
,5
,6
]}

机构：

[1] Univ Arkansas Med Sci, Ctr Osteoporosis & Metab Bone Dis, Div Endocrinol & Metab, Little Rock, AR 72205 USA

[2] Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA

[3] Tokyo Med & Dent Univ, Grad Sch Med & Dent, Dept Cell Signaling, Bunkyo Ku, Tokyo 1138549, Japan

[4] Japan Sci & Technol Agcy JST, Explorat Res Adv Technol ERATO Program, Takayanagi Osteonetwork Project, Bunkyo Ku, Tokyo 1130033, Japan

[5] Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1130033, Japan

[6] Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 1130033, Japan

来源：

BONE | 2013年 / 54卷 / 02期

基金：

日本科学技术振兴机构; 日本学术振兴会; 美国国家卫生研究院;

关键词：

Osteocyte; Osteoclast; Resorption; RANKL; Apoptosis; NF-KAPPA-B; ESTROGEN-RECEPTOR-ALPHA; LIGAND GENE-EXPRESSION; BONE-RESORPTION; 1,25-DIHYDROXYVITAMIN D-3; RHEUMATOID-ARTHRITIS; OSTEOBLASTIC CELLS; DEFECTIVE INTERLEUKIN-1; DIFFERENTIATION FACTOR; MESSENGER-RNA;

D O I：

10.1016/j.bone.2012.08.121

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin. However, the role of osteocytes in the control of bone resorption has been less clear. Recent studies have demonstrated that osteocytes are the major source of the cytokine RANKL involved in osteoclast formation in cancellous bone. The goal of this review is to discuss these and other studies that reveal mechanisms whereby osteocytes control osteoclast formation and thus bone resorption. This article is part of a Special Issue entitled "The Osteocyte". Published by Elsevier Inc.

引用

页码：258 / 263

页数：6

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