Biosynthesis of natural products on modular peptide synthetases

被引：60

作者：

Doekel, S ^{[1
]}

Marahiel, MA ^{[1
]}

机构：

[1] Univ Marburg, Fachbereich Chem Biochem, D-35032 Marburg, Germany

来源：

METABOLIC ENGINEERING | 2001年 / 3卷 / 01期

关键词：

D O I：

10.1006/mben.2000.0170

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Microbial nonribosomally processed peptides represent a large class of natural products including numerous important pharmaceutical agents, as well as other representatives that play a prevalent role in pathogenicity of certain microorganisms [NI. A. Marahiel, T. Stachelhaus, and H. D. Mootz (1997). Chem. Rev. 97, 2651-2673]. Although diverse in structure, nonribosomally synthesized peptides have a common mode of biosynthesis. They are assembled on very large protein templates called peptide synthetases that exhibit a modular organization, allowing polymerization of monomers in an assembly-line-like mechanism. (C) 2001 Academic Press.

引用

页码：64 / 77

页数：14

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