Vitamin D, bone metabolism and fracture risk

被引：3

作者：

Thomas, Thierry ^{[1
]}

Briot, Karine ^{[2
]}

机构：

[1] CHU St Etienne, U1059, INSERM, Serv Rhumatol, St Etienne, France

[2] Hop Cochin, Serv Rhumatol, Paris, France

来源：

GERIATRIE ET PSYCHOLOGIE NEUROPSYCHIATRIE DE VIEILLISSEMENT | 2016年 / 14卷 / 02期

关键词：

BMD; fracture; osteoporosis; vitamin D; CALCIUM-ABSORPTION; D SUPPLEMENTATION; MINERAL DENSITY; DOUBLE-BLIND; WOMEN; PREVENTION; OLDER; MEN; METAANALYSIS;

D O I：

10.1684/pnv.2016.0598

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Insufficient serum levels of 25OH vitamin D (25OHD) is a risk factor for osteoporosis. A new paradigm has emerged with the locally synthesized 1,25(OH) 2D within osteoblasts and osteoclasts as the essential pathway for the effects of 25OHD in regulating bone remodeling via direct or indirect activation of the specific receptor VDR. Vitamin D has positive effects on fracture risk but these results have been consistently observed whenever daily doses were above 800 UI/d administered to compliant patients together with adequate calcium supplementation and with an achieved biological target of serum 25OHD levels above 30 ng/mL.

引用

页码：122 / 126

页数：5

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